2'-Fluoro-2'-deoxyuridine

Bezeichnung:2'-Fluoro-2'-deoxyuridine

CAS-Nr784-71-4

Englisch Name:2'-Fluoro-2'-deoxyuridine

CBNumberCB3358175

SummenformelC9H11FN2O5

Molgewicht246.19

MOL-Datei784-71-4.mol

2'-Fluoro-2'-deoxyuridine physikalisch-chemischer Eigenschaften

Schmelzpunkt	147.0 to 153.0 °C
Dichte	1.63±0.1 g/cm3(Predicted)
Brechungsindex	53 ° (C=0.3, H2O)
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
Löslichkeit	Soluble in methanol.
Aggregatzustand	Powder
pka	9.39±0.10(Predicted)
Farbe	White to Off-white
Optische Aktivität	α20/D +53°±3°, c = 0.3 in water
Wasserlöslichkeit	soluble in water
InChI	InChI=1S/C9H11FN2O5/c10-6-7(15)4(3-13)17-8(6)12-2-1-5(14)11-9(12)16/h1-2,4,6-8,13,15H,3H2,(H,11,14,16)/t4-,6-,7-,8-/m1/s1
InChIKey	UIYWFOZZIZEEKJ-XVFCMESISA-N
SMILES	OC[C@H]1O[C@@H](N2C=CC(=O)NC2=O)[C@H](F)[C@@H]1O
CAS Datenbank	784-71-4(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xn
R-Sätze:	20/21/22-40
S-Sätze:	22-36/37/39
HS Code	29389090

Gefahreninformationscode (GHS)

2'-Fluoro-2'-deoxyuridine Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.
R40:Verdacht auf krebserzeugende Wirkung.
S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
Beschreibung
2'-Deoxy-2'-fluorouridine is a nucleoside analog that inhibits the replication of wild-type viruses by binding to the viral RNA. 2'-Deoxy-2'-fluorouridine has been shown to inhibit the replication of resistant mutants in vitro, and this inhibition can be reversed by increasing the concentration of 2'-deoxy-2'-fluorouridine. 2'-Deoxy-2'-fluorouridine also binds to duplexes of dsDNA with high affinity and specificity.
Chemische Eigenschaften
White to almost white crystalline powder
Verwenden
A component incorporated into therapeutic oligonucleotides to combat prostate and breast cancer.
Verwenden
2'-Fluoro-2'-deoxyuridine is used as a component incorporated into therapeutic oligonucleotides to combat prostate and breast cancer.
Synthese
Method for the synthesis of 2'-Fluoro-2'-deoxyuridine, comprising the following steps:
(1) Uridine, diphenyl carbonate was added in dimethylformamide, dissolved at elevated temperature, the solution was clarified, the catalyst sodium bicarbonate was added under the condition of maintaining temperature, the reaction was carried out at elevated temperature for the second time, the reaction was completed, the temperature was cooled down naturally to room temperature, stirred, filtered, and the cake was dried to obtain compound 2.
(2) Compound 2, anhydrous potassium fluoride, catalyst boron trifluoride ethyl ether dissolved in a solvent, temperature rise reaction, after the completion of the reaction, filtration and concentration, to obtain 2'-fluoro-2'-deoxyuridine.
However, the hydroxyl conversion rate of this method is low, 2'-fluoro-2'-deoxyuridine is an extremely viscous compound, and it cannot be cured and purified when the purity is not high, resulting in the need for the method to be purified by passing through a column at a later stage, and it cannot be used in a factory for continuous and scaled-up production.

2'-Fluoro-2'-deoxyuridine Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

784-71-4, 2'-Fluoro-2'-deoxyuridine Verwandte Suche:

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