Ziconotide Polyacetate

Bezeichnung:Ziconotide Polyacetate

CAS-Nr107452-89-1

Englisch Name:Ziconotide Polyacetate

CBNumberCB3190092

SummenformelC102H172N36O32S7

Molgewicht2639.13

MOL-Datei107452-89-1.mol

Ziconotide Polyacetate physikalisch-chemischer Eigenschaften

Dichte	1.60±0.1 g/cm3(Predicted)
storage temp.	-20°C
Löslichkeit	DMSO (Slightly, Sonicated), Methanol (Slightly)
Aggregatzustand	Solid
Farbe	White to Off-White
InChIKey	BPKIMPVREBSLAJ-QTBYCLKRSA-N

Sicherheit

RIDADR	3172
WGK Germany	3
HazardClass	6.1(b)
PackingGroup	III
Giftige Stoffe Daten	107452-89-1(Hazardous Substances Data)

Gefahreninformationscode (GHS)

Ziconotide Polyacetate Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
ω-conotoxin MVIIA, also knwn as Ziconotide acetate, is a peptide consisting of 25 amino acid. It is a disulfide-bridged polypeptide from the venom of the sea snail Conusmagus that binds to neuronal N-type calcium channels. It forms a compact folded structure, presenting a loop between Cys8 and Cys15 that contains a set of residues critical for its binding. Both ω-conotoxins GVIA and MVIIA could bind to neuronal N-type calcium channels. ω-conotoxin GVIA is rich in hydroxyl groups while ω-conotoxin MVIIA contains a large number of positively charged side chains[1-2].
Verwenden
Ziconotide acetate (ω-Conotoxin MVIIA), the peptide toxin of the Conus magus (cone snail) is a selective antagonist of N-type voltage sensitive calcium channels (VSCC). As a most well-known identified conotoxin so far, it has been used as a effective drug to treat intractable chronic pain in cancer and ADIS patients[2]. Blocks neurotransmitter release by preventing depolarization-induced calcium influx. Used as a ligand for binding studies of voltage sensitive calcium channels. Analgesic; neuroprotective.
Trademarks
Prialt (Elan).
Allgemeine Beschreibung
ω-Conotoxin MVIIA functions as a selective inhibitor of N-type voltage-sensitive calcium channels (VSCCs). It has analgesic and neuroprotective effects. ω-Conotoxin MVIIA is used to treat neuropathic pain.
Biochem/physiol Actions
Neuronal N-type Ca2+ channel blocker in mammalian and amphibian brain; blocks release of GABA and glutamate at neuronal synapses.
Einzelnachweise
[1] Wang R, et al. Development of an ic-ELISA and immunochromatographic strip based on IgG antibody for detection of ω-conotoxin MVIIA. Journal of Hazardous Materials, 2019; 378: 120510.
[2] Zhou Y, et al. A Chemoenzymatic Approach To Produce a Cyclic Analogue of the Analgesic Drug MVIIA (Ziconotide). Angew. Chem. Int. Ed., 2023; 62: e202302812.

Ziconotide Polyacetate Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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