Exenatide acetate

Bezeichnung:Exenatide acetate

CAS-Nr141732-76-5

Englisch Name:Exenatide acetate

CBNumberCB4789871

SummenformelC186H286N50O62S

Molgewicht4244.60796

MOL-Datei141732-76-5.mol

Exenatide acetate physikalisch-chemischer Eigenschaften

Schmelzpunkt	>209°C (dec.)
storage temp.	Refrigerator, under inert atmosphere
Löslichkeit	Acetonitrile (Slightly), Water (Slightly)
Aggregatzustand	Solid
Farbe	White to Off-White
Sequenz	H-His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2
CAS Datenbank	141732-76-5(CAS DataBase Reference)

Exenatide acetate Chemische Eigenschaften,Einsatz,Produktion Methoden

Chemische Eigenschaften
Exenatide acetate is White Solid
Verwenden
Application of exenatide acetate causes an increase in acinar cAMP without stimulating amylase release. As an incretin mimetic, exenatide acetate acts as agonist of the glucagon-like peptide-1 (GLP-1) receptor. As GLP-1, though with prolonged activity, exenatide acetate augments the postprandial production of insulin and suppresses secretion of glucagon. For this reason, exenatide acetate has found use as a medication of diabetes II.
Verwenden
A 39-amino acid peptide originally isolated from the salivary glands of the Gila monster (Heloderma suspectum), differs from exendin-3 only in two positions close to the N-terminus. Application of exenatide causes an increase in acinar cAMP without stimulating amylase release. As an incretin mimetic, exenatide acts as agonist of the glucagon-like peptide-1 (GLP-1) receptor. As GLP-1, though with prolonged activity, exenatide augments the postprandial production of insulin and suppresses secretion of glucagon. For this reason, exenatide has found use as a medication of diabetes II.
Clinical Use
39-peptide known as an incretin mimetic; an agonist of glucagon-like peptide-1, used adjunctively in type II diabetes mellitus.
Arzneimittelwechselwirkung
Potentially hazardous interactions with other drugs
Anticoagulants: possibly enhances anticoagulant effect of warfarin.
Other nephrotoxins: avoid concomitant use.
Stoffwechsel
Exenatide is eliminated through the kidneys by glomerular filtration followed by proteolytic degradation.

Exenatide acetate Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

141732-76-5, Exenatide acetate Verwandte Suche:

Send Inquriy