Lactulose

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Warnung

• Gefahrenhinweise

  H315：Verursacht Hautreizungen.

  H319：Verursacht schwere Augenreizung.

  H335：Kann die Atemwege reizen.

• Sicherheit

  P271：Nur im Freien oder in gut belüfteten Räumen verwenden.

  P280：Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.

Lactulose Chemische Eigenschaften,Einsatz,Produktion Methoden

• S-Sätze Betriebsanweisung:

  S24/25:Berührung mit den Augen und der Haut vermeiden.

• Chemische Eigenschaften

  White Powder

• Originator

  Duphalac,Philips-Duphar,UK,1969

• Verwenden

  A keto analogue of lactose.

• Verwenden

  pharmaceutical excipient

• Verwenden

  Lactulose is is a synthetic, non-digestible sugar used in the treatment of chronic constipation; laxative.

• Definition

  ChEBI: A synthetic galactosylfructose disaccharide used in the treatment of constipation and hepatic encephalopathy.

• Indications

  Osmotic laxatives (e.g., lactulose, sorbitol) are poorly absorbed or nonabsorbable compounds that draw additional fluid into the GI tract. Lumen osmolality increases, and fluid movement occurs secondary to osmotic pressure. Lactulose is a synthetic disaccharide that is poorly absorbed from the GI tract, since no mammalian enzyme is capable of hydrolyzing it to its monosaccharide components. It therefore reaches the colon unchanged and is metabolized by colonic bacteria to lactic acid and to small quantities of formic and acetic acids.

• Manufacturing Process

  105 g of lactose monohydrate were dissolved in 500 ml of water. 48 g of NaAlO2 was dissolved in 100 ml of water and was then added to the lactose solution. The mixture was then diluted to one liter to provide a pH of 11.5. The reactant concentrations of 48 g of sodium aluminate and 105 g of lactose are equivalent to a mol ratio of two mols of aluminate to one mol of lactose. The mixture was then heated to 50°C and 100 ml aliquots were removed at periodic intervals to determine the level of conversion. The reaction was terminated after three hours by adding sufficient 30% HCl to lower the pH to 4.2. The pH was then raised to neutrality, i.e., 6.5 to 7.0, with ammonium hydroxide so as to completely precipitate insoluble aluminum hydroxide. The precipitate was then removed by vacuum filtration and the filtrate was analyzed for the presence of ketose sugar by chromatographic analysis. The chromatographic analysis of the filtrate confirmed that the main component of the filtrate was lactulose and not the monosaccharide ketose sugar, fructose.

• Trademarks

  Cephulac (Sanofi Aventis); Chronulac (Sanofi Aventis); Constulose (Acta- vis); Duphalac (Solvay Pharmaceuticals); Enulose (Actavis); Evalose (Teva); Generlac (Morton Grove); Heptalac (Teva); Laxilose (Technilab); Portalac (Solvay Pharma- ceuticals).

• Therapeutic Function

  Laxative

• Clinical Use

  Lactulose is used in the treatment of hepatic encephalopathy.

• Nebenwirkungen

  Since lactulose does contain galactose, it is contraindicated in patients who require a galactose-free diet. Metabolism of lactulose by intestinal bacteria may result in increased formation of intraluminal gas and abdominal distention.

• Veterinary Drugs and Treatments

  The primary use of lactulose in veterinary medicine is to reduce ammonia blood levels in the prevention and treatment of hepatic encephalopathy (portal-systemic encephalopathy; PSE) in small animals and pet birds. It is also used as a laxative in small animals.

• läuterung methode

  Crystallise lactulose from MeOH or 50% MeOH. It mutarotates from [] D 20 -11.9o to –50.7o (c 1, H2O). [Montgomery & Hudson J Am Chem Soc 32 2101, 2104 1930, Beilstein 17 III/IV 3094, 17/7 V 214.] NMR in Me2SO at 24o shows 0% -pyranose, 27% -pyranose, 20% -furanose and 52% -furanose fforms [Angyal Adv Carbohydr Chem 42 15 1984].

Lactulose Upstream-Materialien And Downstream Produkte

Lactulose Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global(402)Suppliers

4618-18-2, Lactulose Verwandte Suche: