Nefiracetam

Bezeichnung:Nefiracetam

CAS-Nr77191-36-7

Englisch Name:Nefiracetam

CBNumberCB2416333

SummenformelC14H18N2O2

Molgewicht246.3

MOL-Datei77191-36-7.mol

Nefiracetam physikalisch-chemischer Eigenschaften

Schmelzpunkt	151-155°C
Siedepunkt	458.5±33.0 °C(Predicted)
Dichte	1.187±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
Löslichkeit	DMSO: >5mg/mL
pka	13.77±0.70(Predicted)
Aggregatzustand	solid
Farbe	white to off-white
Merck	14,6439
InChI	InChI=1S/C14H18N2O2/c1-10-5-3-6-11(2)14(10)15-12(17)9-16-8-4-7-13(16)18/h3,5-6H,4,7-9H2,1-2H3,(H,15,17)
InChIKey	NGHTXZCKLWZPGK-UHFFFAOYSA-N
SMILES	N1(CC(NC2=C(C)C=CC=C2C)=O)CCCC1=O
CAS Datenbank	77191-36-7(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xn
R-Sätze:	22
WGK Germany	3
RTECS-Nr.	UX9655650
HS Code	2933.79.1500
Toxizität	LD50 in mice (mg/kg): 421 i.v.; 1766 orally (Betzing, 1982)

Gefahreninformationscode (GHS)

Nefiracetam Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
Verwenden
analgesic, antiinflammatory
Verwenden
Nefiracetam improves post-ischemia evoke-nonconvulsive seizure by altering pro-inflammatory cytokines.
Definition
ChEBI: Nefiracetam is an organooxygen compound and an organonitrogen compound. It is functionally related to an alpha-amino acid.
Biologische Aktivität
Cognitive enhancer that displays various pharmacological effects. Activates L/N-type calcium channels, cholinergic, monoaminergic and GABAergic systems. Displays potent neuroprotective action in the retinal ischemia-reperfusion model in vivo .
Mechanism of action
The mechanisms of nefiracetam seem to be linked back to two pathways. One of these pathways prolongs the opening of calcium channels (tied into PKA and a Gi/o protein), which enhances the signalling of a receptor independent of the synapse. The other pathway seems to be tied into PKC and CAMKII, which then augments signalling through cholinergic receptors (which then releases most excitatory neurotransmitters from the presynaptic level, like nicotine). The former pathway (calcium channels) appears critical for long-term potentiation, whereas the latter pathway (PKC/CAMKII) appears vital for neuronal signal enhancement. Some other minor pathways include being a partial agonist at the glycine binding site of the NDMA receptor (may enhance signalling when there are subpar levels of glycine but attenuates excessive signalling) and increasing affinity of the muscarinic acetylcholine receptors for its ligand, acetylcholine.
Lager
Store at RT

Nefiracetam Upstream-Materialien And Downstream Produkte

Nefiracetam Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

77191-36-7, Nefiracetam Verwandte Suche:

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