2-Methoxyphenylboronic acid

Bezeichnung:2-Methoxyphenylboronic acid

CAS-Nr5720-06-9

Englisch Name:2-Methoxyphenylboronic acid

CBNumberCB2264149

SummenformelC7H9BO3

Molgewicht151.96

MOL-Datei5720-06-9.mol

2-Methoxyphenylboronic acid physikalisch-chemischer Eigenschaften

Schmelzpunkt	105-110 °C (lit.)
Siedepunkt	319.3±44.0 °C(Predicted)
Dichte	1.17±0.1 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
Löslichkeit	Chloroform (Slightly), Ethyl Acetate (Slightly)
pka	8.55±0.58(Predicted)
Aggregatzustand	Crystals or Crystalline Powder
Farbe	Off-white
Wasserlöslichkeit	Insoluble in water.
BRN	3030981
InChI	InChI=1S/C7H9BO3/c1-11-7-5-3-2-4-6(7)8(9)10/h2-5,9-10H,1H3
InChIKey	ROEQGIFOWRQYHD-UHFFFAOYSA-N
SMILES	B(C1=CC=CC=C1OC)(O)O
CAS Datenbank	5720-06-9(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	37/39-26-36
WGK Germany	3
TSCA	No
HazardClass	IRRITANT
HS Code	29163990

Gefahreninformationscode (GHS)

2-Methoxyphenylboronic acid Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
2-Methoxyphenylboronic acid is an arylboronic acid. Arylboronic acids can be widely used as safe and environmentally friendly new aromatization reagents for scientific research and production of various fine chemicals containing aryl structures, such as pharmaceuticals, pesticides, and advanced materials. The reactions of arylboronic acids with halogenates play a pivotal role in today's drug synthesis, and such reactions were pioneered by Japanese scientists Suzuki's team, which won the Nobel Prize in Chemistry in 2010.
Chemische Eigenschaften
white to light yellow crystal powder
Verwenden
2-Methoxylphenylboronic acid is a phenylboronic acid used to investigate boron function in plants. It is used in Suzuki reaction, organic reaction that is classified as a coupling reaction where the coupling partners are a boronic acid with a halide catalyzed by a palladium(0) complex.
synthetische
Under the protection of nitrogen, add magnesium (2.9 g, 1.2 times) and tetrahydrofuran (20 ml) and dibromoethane (1.9 g) to a 250 ml three-necked flask with a dropping funnel; then add 2-methoxybromobenzene (17.1 g, 0.1 mol), trimethyl borate (36.8 g, 3.5 times) and tetrahydrofuran (50 ml) as solvent to the dropping funnel. Heat to 40 ℃, activate the magnesium powder, and then slowly add the mixture in the dropping funnel dropwise, control the speed to the reaction temperature does not exceed 60 ℃, add the reaction after stirring until the magnesium basically disappeared, and then heat the reflux reaction for 6 hours. Stop heating, cool to room temperature, hydrolyze with 5% dilute hydrochloric acid to pH<2. Distillation to recover THF solvent, as the solvent is reduced, the product precipitated; cooling and filtration, recrystallization in methanol/water can be obtained 2-methoxyphenylboronic acid.

2-Methoxyphenylboronic acid Upstream-Materialien And Downstream Produkte

2-Methoxyphenylboronic acid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

5720-06-9, 2-Methoxyphenylboronic acid Verwandte Suche:

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