Physostigminsalicylat

Bezeichnung:Physostigminsalicylat

CAS-Nr57-64-7

Englisch Name:PHYSOSTIGMINE SALICYLATE

CBNumberCB2146890

SummenformelC22H27N3O5

Molgewicht413.47

MOL-Datei57-64-7.mol

Synonyma

Physostigminsalicylat

Physostigminsalicylat physikalisch-chemischer Eigenschaften

Schmelzpunkt	181-183 °C
storage temp.	-20°C
Löslichkeit	DMF: 30 mg/ml,DMSO: 10 mg/ml,Ethanol: 1 mg/ml,PBS (pH 7.2): 1 mg/ml
pka	pKa 1.96/8.08(H2O,t =15) (Uncertain)
Merck	7384
BRN	3900576
InChIKey	HZOTZTANVBDFOF-DPKVYHSMNA-N
SMILES	C12C=C(C=CC=1N(C)[C@@]1([H])N(CC[C@@]21C)C)OC(=O)NC.C1(C(=O)O)=CC=CC=C1O \|&1:8,13,r\|
CAS Datenbank	57-64-7(CAS DataBase Reference)
EPA chemische Informationen	Physostigmine salicylate (57-64-7)

Sicherheit

Kennzeichnung gefährlicher	T+
R-Sätze:	26/28
S-Sätze:	25-45
RIDADR	UN 1544 6.1/PG 1
WGK Germany	3
RTECS-Nr.	TJ2450000
HazardClass	6.1(a)
PackingGroup	II
HS Code	2939800000
Toxizität	LD50 i.p. in mice: 0.64 mg/kg (Sofia, Knabloch)

Gefahreninformationscode (GHS)

PHYSOSTIGMINE SALICYLATE Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R26/28:Sehr giftig beim Einatmen und Verschlucken.
S-Sätze Betriebsanweisung:
S25:Berührung mit den Augen vermeiden.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
Chemische Eigenschaften
solid
Verwenden
Physostigmine salicylate (Eserine salicylate) is used as bulk pharmaceuticals (parasympathomimetic, cholinergic, ophthalmic, anti-Alzheimer). Product Data Sheet
Verwenden
cholinergic, anticholinesterase, miotic
Definition
ChEBI: Physostigmine salicylate is an azaheterocycle salicylate salt and a member of salicylates. It contains a physostigmine.
Trademarks
Antilirium (Forest); Isopto Eserine (Alcon).
Allgemeine Beschreibung
The salicylate ofphysostigmine (eserine salicylate) may be prepared byneutralizing an ethereal solution of the alkaloid with anethereal solution of salicylic acid. Excess salicylic acid isremoved from the precipitated product by washing itwith ether. The salicylate is less deliquescent than thesulfate.
Physostigmine salicylate occurs as a white, shining,odorless crystal or white powder that is soluble in water(1:75), alcohol (1:16), or chloroform (1:6) but much lesssoluble in ether (1:250). On prolonged exposure to air andlight, the crystals turn red. The red may be removed bywashing the crystals with alcohol, although this causes lossof the compound as well. Aqueous solutions are neutral orslightly acidic and take on a red coloration after a period.The coloration may be taken as an index of the loss of activityof physostigmine solutions.
Allgemeine Beschreibung
Crystal form that turns red on exposure to heat or light.
Reaktivität anzeigen
Behaves as a weak acid in solution.
Health Hazard
PHYSOSTIGMINE SALICYLATE is similar to physostigmine. It is classified as super toxic. The probable oral lethal dose (humans) is less than 5 mg/kg or a taste for a 150 lb. person. It is a cholinesterase inhibitor.
Brandgefahr
When heated to decomposition, PHYSOSTIGMINE SALICYLATE emits toxic fumes of nitrogen oxides.
Sicherheitsprofil
Poison by ingestion, subcutaneous, intramuscular, intravenous, and intraperitoneal routes. Human systemic effects: arrhythmias, nausea or vomiting. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx See also PHYSOSTIGMINE.

Physostigminsalicylat Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

57-64-7, PHYSOSTIGMINE SALICYLATE Verwandte Suche:

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