1-[[5-(4-Nitrophenyl)furfuryliden]amino]imidazolidin-2,4-dion, Natriumsalz

Bezeichnung:1-[[5-(4-Nitrophenyl)furfuryliden]amino]imidazolidin-2,4-dion, Natriumsalz

CAS-Nr14663-23-1

Englisch Name:Dantrolene sodium salt

CBNumberCB2128232

SummenformelC14H11N4NaO5

Molgewicht338.25

MOL-Datei14663-23-1.mol

Synonyma

1-[[5-(4-Nitrophenyl)furfuryliden]amino]imidazolidin-2,4-dion, Natriumsalz

1-[[5-(4-Nitrophenyl)furfuryliden]amino]imidazolidin-2,4-dion, Natriumsalz physikalisch-chemischer Eigenschaften

storage temp.	Store at RT
Löslichkeit	Soluble in DMSO (up to 3 mg/ml)
Aggregatzustand	Orange solid
Farbe	Orange
Merck	14,2816
Stabilität	Stable for 1 year from date of purchase as supplied. Solutions in DMSO or DMF/ethanol may be stored at -20°C for up to 1 month.
InChIKey	KSRLIXGNPXAZHD-HAZZGOGXSA-M
CAS Datenbank	14663-23-1(CAS DataBase Reference)

Sicherheit

S-Sätze:	22-24/25
WGK Germany	2
RTECS-Nr.	MU3875000
HS Code	2942.00.3500

Gefahreninformationscode (GHS)

Dantrolene sodium salt Chemische Eigenschaften,Einsatz,Produktion Methoden

S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
Beschreibung
Dantrolene is an inhibitor of calcium release from the sarcoplasmic reticulum (IC₅₀ = 0.3 μM). It binds to sarcoplasmic reticulum vesicles isolated from normal and malignant hyperthermia-susceptible (MHS) pigs with K_d values of 0.3 and 0.09 μM, respectively. Dantrolene reduces spontaneous calcium wave frequency and amplitude in the presence of calmodulin in isolated mouse cardiomyocytes with IC₅₀ values of 0.42 and 0.19 μM, respectively. It reduces the magnitude of electrically stimulated twitch tensions in isolated rat extensor digitorum longus and soleus muscles (IC₅₀ = 3 μg/ml) and MHS pigs (ED₅₀ = 0.85 mg/kg). Formulations containing dantrolene have been used in the treatment of malignant hyperthermia.
Chemische Eigenschaften
mp 279-280C 3415821
Verwenden
Dantrolene Sodium Salt is a skeletal muscle relaxant, which inhibits intracellular Ca 2+release from the sarcoplasmic reticulum.
Verwenden
Skeletal muscle relaxant;Blocker of Ca2+ release
Definition
ChEBI: The anhydrous sodium salt of dantrolene.
Trademarks
Dantrium (Procter & Gamble).
Biologische Aktivität
Inhibits release of Ca 2+ from sarcoplasmic reticulum via inhibition of ryanodine receptor (RYR) channels. Displays selectivity for RYR1 and RYR3 over RYR2. Protective against the effects of a variety of conditions and agents, including excitatory amino acids. Skeletal muscle relaxant and neuroprotectant.
Lager
Store at RT
Einzelnachweise
1) Zhao?et al.?(2001),?Dantrolene inhibition of ryanodine receptor Ca2+ release channels. Molecular mechanism and isoform selectivity; J. Biol. Chem.,?276?13810 2) Frandsen and Schousboe (1992),?Mobilization of dantrolene-sensitive intracellular calcium pools is involved in the cytotoxicity induced by quisqualate and N-methyl-D-aspartate but not by 2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionate and kainite in cultured cerebral cortical neurons; Proc. Natl. Acad. Sci. USA,?89?2590 3) Muehlschlegel and Sims (2009),?Dantrolene: mechanisms of neuroprotection and possible clinical applications in the neurointensive care unit; Neuro. Crit. Care,?10?103 4) Lu?et al.?(2014),?A calcium-dependent protease as a potential therapeutic target for Wolfram syndrome; Proc. Natl. Acad. Sci. USA,?111?E5292

1-[[5-(4-Nitrophenyl)furfuryliden]amino]imidazolidin-2,4-dion, Natriumsalz Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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