Polygalacic acid

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Warnung

Polygalacic acid Chemische Eigenschaften,Einsatz,Produktion Methoden

• Verwenden

  Polygalacic acid can be used to calm the nerves, eliminate phlegm, reduce swelling, etc. It is mostly used clinically to treat bronchitis, induce labor, and induce labor.

• Biologische Aktivität

  Polygalacic acid is a triterpenoid tetrahydroxy acid isolated from Polygala paenea L.. It (0-100μM; 24h) can significantly reduce the mRNA expression of MMP-3, MMP-9, MMP-13 and COX-2, and the expression of these factors can be significantly increased by IL-1β in a dose-dependent manner .

• in vitro

  Polygalacic acid (0-100 μM; 24 hours) significantly decreases the mRNAexpressions of MMP-3, MMP-9, MMP-13, and COX-2, which are significantly increased by IL-1β, in a In a dose-dependent manner. Polygalacic acid (0-100 μM; 6 hours) decreases the expression of phosphor-p38, phosphor-Erk, and phosphor-Jnk induced by IL-1β, phosphor-p65 is not reduced by polygalacic acid.

  RT-PCR

  Cell Line:	Chondrocyte cells
  Concentration:	50 μM; 100 μM
  Incubation Time:	24 hours
  Result:	Suppressed IL-1β-induced COX-2, MMP3, MMP9, and MMP13 mRNA expression.

  Western Blot Analysis

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  Cell Line:	Chondrocyte cells
  Concentration:	50 μM; 100 μM
  Incubation Time :	6 hours
  Result:	Inhibited the IL-1β-induced activation of the MAPK pathway in chondrocytes.

Polygalacic acid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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