(20R,25R)-Spirost-5-en-3β-ol Produkt Beschreibung

Diosgenin Struktur
512-04-9
  • CAS-Nr.512-04-9
  • Bezeichnung:(20R,25R)-Spirost-5-en-3β-ol
  • Englisch Name:Diosgenin
  • Synonyma:(20R,25R)-Spirost-5-en-3β-ol
    SP 37;C08898;diosgen;SAPOGENIN;NITOGENIN;DIOSGENIN;Diosgemom;(3β,25R)-;Nitrogenin;Diosgenin,95%
  • CBNumber:CB2685481
  • Summenformel:C27H42O3
  • Molgewicht:414.62
  • MOL-Datei:512-04-9.mol
(20R,25R)-Spirost-5-en-3β-ol physikalisch-chemischer Eigenschaften
  • Schmelzpunkt: :205-208°C
  • alpha  :D25 -129° (c = 1.4 in CHCl3)
  • Siedepunkt: :473.46°C (rough estimate)
  • Dichte :1.0483 (rough estimate)
  • Brechungsindex :1.4700 (estimate)
  • storage temp.  :Refrigerator
  • Löslichkeit :chloroform: 20 mg/mL, clear, slightly yellow
  • pka :15.02±0.70(Predicted)
  • Wasserlöslichkeit :Soluble in chloroform (50 mg/ml), ethanol (83 mg/ml at 25°C), water (<1 mg/ml at 25°C), DMSO (<1 mg/ml at 25°C), and methanol.
  • Merck  :14,3295
  • BRN  :94582
  • CAS Datenbank :512-04-9(CAS DataBase Reference)
  • NIST chemische Informationen :Diosgenin(512-04-9)
Sicherheit
  • Kennzeichnung gefährlicher :Xi
  • R-Sätze: :36/37/38
  • S-Sätze: :26-36/37-24/25
  • WGK Germany  :2
  • RTECS-Nr. :WH1450000
  • HS Code  :29329990

Diosgenin Chemische Eigenschaften,Einsatz,Produktion Methoden

  • R-Sätze Betriebsanweisung: R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
  • S-Sätze Betriebsanweisung: S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
    S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
  • Chemische Eigenschaften White to Off-White Dolid
  • Verwenden antiinflammatory, estrogen
  • Verwenden Aglicone of saponin dioscin. Diosgenin exists in some food supplements and herbal medicines and lowers plasma cholesterol by increasing fecal cholesterol excretion. e and Progesterone.
  • Verwenden pregnenolone and progesterone precursor
  • Anticancer Research It is a steroidal saponin and legumes and yams are the rich sources of it. It is a notoriousprecursor of several synthetic steroidal drugs. It suppresses growth of cells andinduces apoptosis in human osteosarcoma, colon cancer, and leukemia. Its anticancermechanism is by arresting the cell cycle, disrupting the calcium homeostasis,activating p53, releasing apoptosis inducing factors, and modulating caspase-3activity. It suppresses NF-κB activation induced by TNF as a result of DNA binding,IκBα kinase activation, degradation, phosphorylation, p65 nuclear translocation,and phosphorylation. It suppresses proliferation and invasion and induces apoptosisby downregulation of cFLIP, cyclin-D1, TRAF1, COX-2, c-myc, Bfl-1/A1, BclxL,IAP1, Bcl-2, and MMP-9 (Aggarwal et al. 2008; Raju and Mehta 2008).
  • läuterung methode Crystallise diosgenin from acetone, and chromatograph it on Al2O3 and elute with *C6H6/Et2O (9:1), then recrystallise it from MeOH. Its solubility is ~4% in H2O and 5% in CHCl3. The acetate crystallises from AcOH with m 198o; and has [] D 20 -119o (pyridine). [Marker et al. J Am Chem Soc 65 1199 1943. Mazur et al. J Am Chem Soc 82 5889 1960, Beilstein 19 IV 862.]
Diosgenin Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
(20R,25R)-Spirost-5-en-3β-ol Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
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512-04-9, Diosgenin Verwandte Suche:
  • 5,20-ALPHA, 22-ALPHA, 25D-SPIROSTEN-3-BETA-OL
  • 5, 20, 22, 25D-SPIROSTEN-3-OL
  • [25R]-5-SPIROSTEN-3BETA-OL
  • (25R)-Spirost-5-en-3beta-ol
  • NITOGENIN
  • SAPOGENIN
  • (25r)-spirost-5-en-3-beta-o
  • (25R)-Spirost-5-en-3b-ol
  • (25R)-Spirost-5-en-3-ol
  • (3.beta.,25R)-Spirost-5-en-3-ol
  • (3-beta,25r)-spirost-5-en-3-o
  • Spirost-5-en-3-ol deriv.
  • Spirost-5-en-3-ol, (3b,25R)-
  • Spirost-5-en-3-ol, (3beta,25R)-
  • (20R,25R)-spirost-5-en-3-beta-ol
  • Diosgenin,95%
  • 6-Keto Diosgenin
  • (25R)-5-Spirostene-3-beta-ol
  • Diosgenin=Nitogenin
  • (25r)-5-spirosten-3β-ol
  • C08898
  • DIOSGENIN(SAPOGENIN)(P)
  • DIOSGENIN(SAPOGENIN)(SH)
  • DIOSGENIN & DERIVATIVES
  • Diosgenin/Dioscin/Dioscorea zingiberensis
  • Wild Yam Extract/Diosgenin
  • (3β,25R)-Spirost-5-en-3-ol
  • Diosgenin 512-04-9
  • DIOSGENIN
  • HYDROXY-5-SPIROSTENE
  • 3b-hydroxy-5-spirostene
  • 3BETA-HYDROXY-5-SPIROSTENE
  • 5,25R-SPIROSTEN-3BETA-OL
  • 20F,22F-Spirosten-3-ol
  • 22alpha-Spirost-5-en-3beta-ol
  • 25d-Spirost-5-en-3b-ol
  • 5-22-Spirosten-3-ol
  • 5-25D-Spirosten-3-ol
  • delta 5,20a,22a,25D-spirosten-3beta-ol
  • Nitrogenin
  • SP 37
  • Spiro(8H-naphth(2',1':4,5)-indeno(2,1-b)furan-8,2'-(2H)-pyran)-2-ol, 1,2,3,3',4,4',4a,4b,5,5',6,6',6a,6b,7,9a,10,10a,10b,11-eicosahydro-4a,5',6a,7-tetramethyl-
  • Spiro[8H-naphth[2',1':4,5]indeno[2,1-b]furan-8,2'-[2H]pyran],
  • Spiro[8H-naphth[2',1':4,5]indeno[2,1-b]furan-8,2'-[2H]pyran], spirost-5-en-3-ol deriv.
  • Spirost-5-en-3beta-ol, (25R)-
  • Spirost-5-en-3b-ol, (25R)-
  • Spirost-5-en-3-ol
  • Diosgemom
  • DIOCTYLMALONATE
  • DIOSGENIN (3B-HYDROXY-5A-SPIROSCENE)
  • (25R)-5-Spirosten-3β-ol, 3β-Hydroxy-5-spirostene
  • (25R)-5-Spirosten-3b-ol
  • (25R)-3β-Hydroxyspirosta-5-ene
  • 3β-Hydroxy-5-spirostene
  • Diosgenin,(25R)-5-Spirosten-3β-ol, 3β-Hydroxy-5-spirostene
  • 5,7',9',13'-tetraMethyl-5'-oxaspiro[oxane-2,6'-pentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icosan]-18'-en-16'-ol
  • (3β,25R)-
  • Dioscorea sapogenin