3-Acetamido-2,4,6-triiod-5-N-methylacetamidobenzoesure

Bezeichnung:3-Acetamido-2,4,6-triiod-5-N-methylacetamidobenzoesure

CAS-Nr1949-45-7

Englisch Name:Metrizoic acid

CBNumberCB1775662

SummenformelC12H11I3N2O4

Molgewicht627.94

MOL-Datei1949-45-7.mol

Synonyma

3-Acetamido-2,4,6-triiod-5-N-methylacetamidobenzoesure

3-Acetamido-2,4,6-triiod-5-N-methylacetamidobenzoesure physikalisch-chemischer Eigenschaften

Schmelzpunkt	281-282°
Siedepunkt	678.8±55.0 °C(Predicted)
Dichte	2.3140 (estimate)
storage temp.	2-8°C(protect from light)
Löslichkeit	DMSO
Aggregatzustand	Solid
pka	0.82±0.10(Predicted)
Farbe	White
Merck	14,6156
CAS Datenbank	1949-45-7(CAS DataBase Reference)
EPA chemische Informationen	Benzoic acid, 3-(acetylamino)-5-(acetylmethylamino)-2,4,6-triiodo- (1949-45-7)

Sicherheit

R-Sätze:	36/37/38
S-Sätze:	26-36/37/39
RTECS-Nr.	DG0887300
HS Code	2924.29.7790

Gefahreninformationscode (GHS)

Metrizoic acid Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
Originator
Isopaque,Winthrop,France,1973
Verwenden
Diagnosis aid (radiopaque medium).
Definition
ChEBI: Metrizoic acid is a monocarboxylic acid. It has a role as a radioopaque medium.
Manufacturing Process
3,5-Diacetamido-2,4,6-triiodobenzoic acid (diatrizoic acid) (see Diatrizoate entry for synthesis) (10 g) is suspended in water (10 ml), 5 N potassium hydroxide (4.3 equivalent) is added and the mixture cooled to about 15°C. Dimethyl sulfate (0.5 equivalent) dissolved in an equal volume of acetone is added drop by drop while stirring. After the reaction mixture has been stirred for about 1 hour hydrochloric acid (1:1) is added, with stirring to pH about 0.5. The precipitate is filtered, washed and suspended moist in 4 parts of water, concentrated ammonia is added to pH about 7 and the ammonium salt solution is isomerized at 90°C to 100°C for about one-half hour whereafter additional ammonia is added to pH about 9 followed by solid ammonium chloride (about 10% weight/volume) and the solution stirred overnight and the excess of 3,5-diacetamide-2,4,6-triiodobenzoic acid recovered as ammonium salt on the filter. The filtrate is precipitated by means of hydrochloric acid (1:1 ) at pH about 0.5 and the N-methyl-3,5-diacetamido- 2,4,6-triiodobenzoic acid collected on a filter, washed and dried.
Therapeutic Function
Diagnostic aid (radiopaque medium)

Metrizoic acid Upstream-Materialien And Downstream Produkte

3-Acetamido-2,4,6-triiod-5-N-methylacetamidobenzoesure Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

1949-45-7, Metrizoic acid Verwandte Suche:

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