Adipiodon

Bezeichnung:Adipiodon

CAS-Nr606-17-7

Englisch Name:IODIPAMIDE

CBNumberCB3125304

SummenformelC20H14I6N2O6

Molgewicht1139.76

MOL-Datei606-17-7.mol

Synonyma

Adipiodon

Adipiodon physikalisch-chemischer Eigenschaften

Schmelzpunkt	306-308°C (dec.)
Siedepunkt	908.6±65.0 °C(Predicted)
Dichte	2.5848 (estimate)
Brechungsindex	nD21.5 1.3294 (c = 0.445 in methanol)
storage temp.	Room Temperature
Löslichkeit	DMSO (Slightly), Methanol (Very Slightly)
pka	pKa 3.5(H2O) (Uncertain)
Farbe	White
Wasserlöslichkeit	0.46g/L(20 ºC)
Merck	5022
EPA chemische Informationen	Benzoic acid, 3,3'-[(1,6-dioxo-1,6-hexanediyl)diimino]bis[2,4,6-triiodo- (606-17-7)

Sicherheit

WGK Germany	3
RTECS-Nr.	DG0949500
HS Code	2924296000
Giftige Stoffe Daten	606-17-7(Hazardous Substances Data)
Toxizität	LD50 in mice, rats (mg/kg): 2380 ±290, 4430 ±310 i.v. (Rosenberg)

Gefahreninformationscode (GHS)

IODIPAMIDE Chemische Eigenschaften,Einsatz,Produktion Methoden

Chemische Eigenschaften
Crystalline Solid
Originator
Cholografin,Squibb,US,1954
Verwenden
antihypertensive, diuretic, activates K channels and AMPA receptors
Verwenden
Diagnostic aid (radiopaque medium-cholecystographic).
Definition
ChEBI: Adipiodone is an organoiodine compound that is 3-amino-2,4,6-triiodobenzoic acid in which one of the amino hydrogens is substituted by a 6-(3-carboxy-2,4,6-triiodoanilino)-6-oxohexanoyl group. It is a water-soluble radiographic contrast media for cholecystography and intravenous cholangiography. It has a role as a radioopaque medium. It is an organoiodine compound, a member of benzoic acids and a secondary carboxamide. It is a conjugate acid of an adipiodone(2-).
Manufacturing Process
125 g of 2,4,6-triiodo-3-amino benzoic acid are dissolved in 250 cc of chlorobenzene and 15 g of adipic acid dichloride are added at a temperature between 110° and 130°C drop by drop to the solution. After evolution of hydrochloric acid (about 2 to 3 hours) has ceased, the precipitated crude adipic acid di-(3-carboxy-2,4,6-triiodo anilide) of the above formula is filtered hot with suction, washed with chlorobenzene, extracted by boiling with methanol and, for purification, dissolved in an amount of methanolic caustic soda solution required for neutralization, filtered with charcoal, and precipitated with dilute hydrochloric acid. Yield: 82.3 g, MP 306° to 308°C (with decomposition).
Trademarks
Pharmaceutic necessity for Iodipamide Meglumine [Injection]. Cholografin (Bristol-Myers Squibb).
Therapeutic Function
Diagnostic aid (radiopaque medium)
Hazard
Toxic by ingestion.

IODIPAMIDE Upstream-Materialien And Downstream Produkte

Adipiodon Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

606-17-7, IODIPAMIDE Verwandte Suche:

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