2-Iodbenzoesure

Bezeichnung:2-Iodbenzoesure

CAS-Nr88-67-5

Englisch Name:2-Iodobenzoic acid

CBNumberCB1126640

SummenformelC7H5IO2

Molgewicht248.02

MOL-Datei88-67-5.mol

Synonyma

2-Iodbenzoesure

2-Iodbenzoesure physikalisch-chemischer Eigenschaften

Schmelzpunkt	160-162 °C(lit.)
Siedepunkt	313.9±25.0 °C(Predicted)
Dichte	2.25
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
Löslichkeit	Soluble in dimethyl sulfoxide and methanol
pka	2.85(at 25℃)
Aggregatzustand	Powder, Crystals or Flakes
Farbe	Light yellow to orange-brown
Wasserlöslichkeit	sparingly soluble
Sensitive	Light Sensitive
Merck	14,5030
BRN	1861406
Stabilität	Stable. Incompatible with strong oxidizing agents, strong bases.
InChIKey	CJNZAXGUTKBIHP-UHFFFAOYSA-N
CAS Datenbank	88-67-5(CAS DataBase Reference)
NIST chemische Informationen	Benzoic acid, 2-iodo-(88-67-5)
EPA chemische Informationen	Benzoic acid, 2-iodo- (88-67-5)

Sicherheit

Kennzeichnung gefährlicher	Xn,Xi
R-Sätze:	22-37/38-41-36/37/38-20/21/22
S-Sätze:	26-39-24/25-22-36
WGK Germany	3
RTECS-Nr.	DH2975000
Hazard Note	Irritant
TSCA	T
HazardClass	IRRITANT, LIGHT SENSITIVE
HS Code	29163900

Gefahreninformationscode (GHS)

2-Iodobenzoic acid Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
R37/38:Reizt die Atmungsorgane und die Haut.
R41:Gefahr ernster Augenschäden.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S39:Schutzbrille/Gesichtsschutz tragen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
S22:Staub nicht einatmen.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
2-iodobenzoic acid and its derivatives are important pharmaceutical and chemical raw materials, which are necessary for the synthesis of various high-iodine reagents. It is commonly used as a precursor for the synthesis of 2-Iodoxybenzoic acid (IBX) and Dess-Martin peridinane, which are used as mild oxidants. It is also used in Suziki reaction.
Chemische Eigenschaften
white crystal powder. Soluble in alcohol and ether, insoluble in water.
Verwenden
Reagent for detection of sulfhydryl groups in proteins. 2-Iodobenzoic acid acts as a precursor in the preparation of 2-Iodoxybenzoic acid (IBX) and Dess-Martin periodinane, which finds application as an oxidizing agent in synthetic chemistry. It is also used in Suzuki reaction.
Application
2-Iodobenzoic acid can be used as a reactant in the synthesis of oligo(m-phenylene ethynylenes), (±)-lycoricidine and various detoxifiers of organophosphorus nerve agents. Additionally, it is used as a precursor in the preparation of oxidizing reagents like 2-iodoxybenzoic acid (IBX) and Dess-Martin periodinane (DMP).
synthetische
2-Iodobenzoic acid is obtained from Anthranilic acid by diazotization and substitution. Diazotization of Anthranilic acid with sodium nitrite in the presence of sulfuric acid, control the temperature below 10℃, filter the diazotization solution, add the mixture of potassium iodide and sulfuric acid, stir for 10min after addition, and boil. Filter, wash with sodium thiosulfate solution, 2-Iodobenzoic acid can be recrystallized from water.
Definition
ChEBI: An iodobenzoic acid with a single iodo substituent placed at the 2-position.
Synthesis Reference(s)
Journal of the American Chemical Society, 93, p. 4841, 1971 DOI: 10.1021/ja00748a029
läuterung methode
Crystallise the acid repeatedly from water and EtOH. Sublime it under vacuum at 100o. [Beilstein 9 IV 1030.]

2-Iodobenzoic acid Upstream-Materialien And Downstream Produkte

2-Iodbenzoesure Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

88-67-5, 2-Iodobenzoic acid Verwandte Suche:

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