1,2-Benzisothiazol-3(2H)-on

Bezeichnung:1,2-Benzisothiazol-3(2H)-on

CAS-Nr2634-33-5

Englisch Name:1,2-Benzisothiazol-3(2H)-one

CBNumberCB1496512

SummenformelC7H5NOS

Molgewicht151.19

MOL-Datei2634-33-5.mol

Synonyma

1,2-Benzisothiazol-3(2H)-on

1,2-Benzisothiazol-3(2H)-on physikalisch-chemischer Eigenschaften

Schmelzpunkt	154-158 °C(lit.)
Siedepunkt	360°C (rough estimate)
Dichte	1.2170 (rough estimate)
Dampfdruck	0Pa at 25℃
Brechungsindex	1.5500 (estimate)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
Löslichkeit	Soluble in dichloromethane, dimethyl sulfoxide, methanol.
pka	10.19±0.20(Predicted)
Aggregatzustand	Solid
Farbe	White to Light yellow to Light orange
Biologische Quelle	rabbit
Wasserlöslichkeit	1.288g/L at 20℃
Major Application	cleaning products cosmetics environmental food and beverages personal care
Kosmetik-Inhaltsstoffe Funktionen	ANTIMICROBIAL
InChI	1S/C7H5NOS/c9-7-5-3-1-2-4-6(5)10-8-7/h1-4H,(H,8,9)
InChIKey	DMSMPAJRVJJAGA-UHFFFAOYSA-N
SMILES	Oc1nsc2ccccc12
LogP	0.7 at 20℃
CAS Datenbank	2634-33-5
EPA chemische Informationen	1,2-Benzisothiazolin-3-one (2634-33-5)

Sicherheit

Kennzeichnung gefährlicher	Xn,N
R-Sätze:	22-38-41-43-50
S-Sätze:	24-26-37/39-61
RIDADR	UN 3077 9/PG 3
WGK Germany	2
RTECS-Nr.	DE4620000
TSCA	TSCA listed
HazardClass	9
HazardClass	IRRITANT
PackingGroup	Ⅲ
HS Code	29339900
Speicherklasse	11 - Combustible Solids
Hazard Classifications	Acute Tox. 4 Oral Aquatic Acute 1 Eye Dam. 1 Skin Irrit. 2 Skin Sens. 1
Giftige Stoffe Daten	2634-33-5(Hazardous Substances Data)
Toxizität	LD50 oral in rat: 1020mg/kg

Gefahreninformationscode (GHS)

1,2-Benzisothiazol-3(2H)-one Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
R38:Reizt die Haut.
R41:Gefahr ernster Augenschäden.
R43:Sensibilisierung durch Hautkontakt möglich.
R50:Sehr giftig für Wasserorganismen.
S-Sätze Betriebsanweisung:
S24:Berührung mit der Haut vermeiden.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S61:Freisetzung in die Umwelt vermeiden. Besondere Anweisungen einholen/Sicherheitsdatenblatt zu Rate ziehen.
Beschreibung
BIT (1,2-Benzisothiazol-3(2H)-one) is an irritant and also a skin sensitizer. Occupational allergie contact dermatitis has been reported mainly related to the use of cutting oils and greases in paint manufacturers, pottery mouldmakers, acrylic emulsion manufacturers, plumbers, printers and lithoprinters, paper makers, an analyticallaboratory, a rubber factory, and in employees manufacturing air fresheners.
Chemische Eigenschaften
Yellow Powder
Verwenden
Isothiazolinone BIT is widely used in industry as a preservative in water-based solutions, such as pastes, paints and cutting oils. It exists at different concentrations in the different Proxel AB, GXL, CRL, XL2, XL, HL, TN, and in Mergal K-10.
Verwenden
Antimicrobial agent.
Definition
ChEBI: Benzo[d]isothiazol-3-one is an organic heterobicyclic compound based on a fused 1,2-thiazole and benzene bicyclic ring skeleton, with the S atom positioned adjacent to one of the positions of ring fusion. It has a role as a disinfectant, a platelet aggregation inhibitor, an environmental contaminant, a xenobiotic, a drug allergen and a sensitiser. It is an organonitrogen heterocyclic compound and an organic heterobicyclic compound.
Application
1,2-benzisothiazol-3(2H)-one (BIT) has been widely used in high concentrations for microbial growth control in many domestic and industrial processes, its potential eco-risk should be assessed.
Allgemeine Beschreibung
1,2-Benzisothiazol-3(2H)-one is a commonly used biocide in industrial and consumer products, which possesses antimicrobial activity against gram positive and gram negative bacteria. It is mainly used in packaging, adhesives, detergents, disinfectants, sunscreen lotions, paints and lubricants.
Flammability and Explosibility
Not classified
Kontakt-Allergie
1,2-Benzisothiazol-3(2H)-one, both an irritant and a skin sensitizer, is widely used in industry as a preservative in water-based solutions such as pastes, paints, and cutting oils. Occupational dermatitis has been reported mainly due to cutting fluids and greases, in paint manufacturers, pottery moldmakers, acrylic emulsions manufacturers, plumber,printers and lithoprinters, paper makers, analytical laboratory, rubber factory, and employees manufacturing air fresheners. It is also a preservative in vinyl gloves.
Sicherheitsprofil
Moderately toxic by ingestion.When heated to decomposition it emits toxic vapors ofNOx and SOx.
Toxicity evaluation
Isothiazolinones, such as 1,2-benzisothiazol-3(2H)-one (BIT), are widely used as biocides for bacterial growth control in many domestic and industrial processes. Despite their advantages as biocides, they are highly toxic and pose a potential risk to the environment. BIT could seriously inhibit the growth of Scenedesmus sp. LX1, Chlorella sp. HQ, and Chlamydomonas reinhardtii with half maximal effective concentrations at 72 h (72h-EC50) of 1.70, 0.41, and 1.16 mg/L, respectively. The primary inhibition mechanism was the BIT-induced damage to microalgal photosynthetic systems.
Filter für giftige stoffe
The Initial Threshold Screening Level (ITSL) for 1,2-benzisothiazol-3(2H)-one of 0.1 μg/m3 with annual averaging time is being rescinded.

1,2-Benzisothiazol-3(2H)-one Upstream-Materialien And Downstream Produkte

1,2-Benzisothiazol-3(2H)-on Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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