1-((2-(2,4-Dichlorphenyl)-4-pro-pyl-1,3-dioxalan-2-yl)methyl)-1H-1,2,4-triazol

Bezeichnung:1-((2-(2,4-Dichlorphenyl)-4-pro-pyl-1,3-dioxalan-2-yl)methyl)-1H-1,2,4-triazol

CAS-Nr60207-90-1

Englisch Name:Propiconazole

CBNumberCB0403173

SummenformelC15H17Cl2N3O2

Molgewicht342.22

MOL-Datei60207-90-1.mol

Synonyma

1-[[2-(2,4-Dichlorphenyl)-4-propyl-1,3-dioxolan-2-yl]methyl]-1H-1,2,4-triazol

1-((2-(2,4-Dichlorphenyl)-4-pro-pyl-1,3-dioxalan-2-yl)methyl)-1H-1,2,4-triazol

1-((2-(2,4-Dichlorphenyl)-4-pro-pyl-1,3-dioxalan-2-yl)methyl)-1H-1,2,4-triazol physikalisch-chemischer Eigenschaften

Schmelzpunkt	<25 °C
Siedepunkt	180°C (0.1 torr)
Dichte	1.2700
Dampfdruck	5.6 x l0^-5 Pa (25 °C)
Brechungsindex	1.6100 (estimate)
Flammpunkt	11 °C
storage temp.	APPROX 4°C
Löslichkeit	DMF: 33 mg/ml,DMF:PBS (pH 7.2)(1:3): 0.16 mg/ml,DMSO: 20 mg/ml,Ethanol: 10 mg/ml
Wasserlöslichkeit	100 mg l^-1(2O °C)
pka	2.94±0.12(Predicted)
Aggregatzustand	Oil
Wichte	1.29 (20℃)
Merck	13,7910
BRN	9349305
Stabilität	Stable. Incompatible with strong oxidizing agents.
InChIKey	STJLVHWMYQXCPB-UHFFFAOYSA-N
LogP	3.7 at 25℃
CAS Datenbank	60207-90-1(CAS DataBase Reference)
EPA chemische Informationen	Propiconazole (60207-90-1)

Sicherheit

Kennzeichnung gefährlicher	Xn,N,T,F
R-Sätze:	22-43-50/53-39/23/24/25-23/24/25-11
S-Sätze:	36/37-46-60-61-45-16-7
RIDADR	UN3082 9/PG 3
WGK Germany	3
RTECS-Nr.	XZ4620000
HS Code	29349990
Giftige Stoffe Daten	60207-90-1(Hazardous Substances Data)
Toxizität	LD50 orally in rats: 1517 mg/kg (Urech)

Gefahreninformationscode (GHS)

Propiconazole Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
R43:Sensibilisierung durch Hautkontakt möglich.
R50/53:Sehr giftig für Wasserorganismen, kann in Gewässern längerfristig schädliche Wirkungen haben.
R39/23/24/25:Giftig: ernste Gefahr irreversiblen Schadens durch Einatmen, Berührung mit der Haut und durch Verschlucken.
R23/24/25:Giftig beim Einatmen, Verschlucken und Berührung mit der Haut.
R11:Leichtentzündlich.
S-Sätze Betriebsanweisung:
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
S46:Bei Verschlucken sofort ärztlichen Rat einholen und Verpackung oder Etikett vorzeigen.
S60:Dieses Produkt und sein Behälter sind als gefährlicher Abfall zu entsorgen.
S61:Freisetzung in die Umwelt vermeiden. Besondere Anweisungen einholen/Sicherheitsdatenblatt zu Rate ziehen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S16:Von Zündquellen fernhalten - Nicht rauchen.
S7:Behälter dicht geschlossen halten.
Beschreibung
Propiconazole is a mixture of four stereoisomers and was first developed in 1979 by Janssen Pharmaceutical of Belgium.
Chemische Eigenschaften
Colorless solid or a yellow thick liquid. Odorless. Commercial product is available as an emulsifi- able concentrate. Physical and toxicological properties may be affected by carrier solvents in commercial formulations.
Chemische Eigenschaften
normally provided as a yellow liquid
Verwenden
Agricultural fungicide.
Verwenden
Propiconazole is a triazole-based fungicide that is used to control fungi in agriculture, on turf, and in wood.
Verwenden
Labelled Propiconazole (P770100). Systemic foliar fungicide. Agricultural fungicide.
Definition
ChEBI: Propiconazole is the cyclic ketal obtained by formal condensation of 1-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanone with pentane-1,2-diol. A triazole fungicide, it is used commercially as a diastereoisomeric mixture on soft fruit (including apricots, peaches, nectarines, plums and prunes), nuts (including peanuts, pecans and almonds), mushrooms, and grasses grown for seeds. It has a role as a xenobiotic, an environmental contaminant, an EC 1.14.13.70 (sterol 14alpha-demethylase) inhibitor and an antifungal agrochemical. It is a member of triazoles, a cyclic ketal, a dichlorobenzene, a conazole fungicide and a triazole fungicide.
Allgemeine Beschreibung
Yellowish odorless liquid. Non corrosive. Used as a fungicide.
Reaktivität anzeigen
A triazole derivative.
Flammability and Explosibility
Not classified
Landwirtschaftliche Anwendung
Fungicide: Used to control fungi on a broad range of crops and turf. Used on ornamentals, range land and rights-of-way to prevent and control powdery mildew and fungi on hardwoods and conifers.
Handelsname
ALAMO®; BANNER®; BENIT®; BREAK®; BUMPER®; CGA-64250®; CGA-92710 F®; DESMEL®; FIDIS®; JUNO®; MANTI® S; MAXX®; NOVEL®; ORBIT®; PRACTIS®; PROPIMAX®; RADAR®; RESTORE®; SPIRE®; STRATEGO® (trifloxystrobin + propiconazole); TASPA®; TILT®; WOCOSIN®
mögliche Exposition
Propiconazole is a triazole fungicide used to control fungi on a broad range of crops and turf. Used on ornamentals, range land and rights-of-way to pre- vent and control powdery mildew and fungi on hardwoods and conifers.
Environmental Fate
Routes and Pathways, and Relevant Physicochemical Properties Log Kow＝3.72
Solubilities: 47 g l1 in n-hexane; completely miscible with ethanol, acetone, toluene, and octanol; soluble in most organic solvents; in water ＝ 100 mg l^-1 at 25°C
Henry's law constant＝ 4.1×10^-9 atm-cu mmol^-1 at 25°C
Partition Behavior in Water, Sediment, and Soil Terrestrial Fate
Propiconazole penetrates the terrestrial environment in its function as a fungicide for a variety of crops. In the terrestrial environment, propiconazole is presented to be slightly persistent to persistent. Biotransformation is an important route of transformation for propiconazole, with major transformation products being 1,2,4-triazole and compounds hydroxylated at the dioxolane moiety. Phototransformation on soil or in air is not important for propiconazole transformation. Propiconazole appears to have medium to low mobility in soil. It has the potential to reach ground water through leaching, especially in soils with low organic matter content. Propiconazole is typically detected in the upper soil layers, but transformation products were detected deeper in the soil profile.
Environmental Persistency
Propiconazole is persistent and relatively immobile in most soil and aqueous environments. Propiconazole degradation in the aquatic environment appears to be dependent solely on aqueous photolysis. In the soil, propiconazole dissipation appears to be dependent on binding to soil organic matter content. The average half-life in soils ranges from months to a year.
Propiconazole is expected to biodegrade in the environment. The estimated half-life of propiconazole in aerobic soils is about 40–70 days, and in aerobic waters is about 25–85 days. Based on monitoring data and field tests, propiconazole has an estimated half-life of about 60–96 days in typical soils. No hydrolysis of propiconazole at environmentally relevant pH has been observed.
Propiconazole degrades into triazole compounds, which may still be toxic. Decomposition of propiconazole by heating may release toxic gases.
Stoffwechselwegen
The numerous metabolites of propiconazole are identified from rat urine and feces. Major sites for enzymatic attack are the propyl side chain and the cleavage of the dioxane ring. The 2,4-dichlorophenyl ring is attacked in various ways including the formation of a cyclohexadiene ring system, hydroxylation, replacement of the chlorine substituent by a hydroxy group, and introduction of a methylthio group. The 1,2,4-triazole ring is oxidatively attacked, leading to hydroxy derivatives. The vast majority of the alcoholic and phenolic metabolites are excreted as sulfuric acid and glucuronic acid conjugates. The major metabolic pathway in mice is via cleavage of the dioxane ring. Photolysis causes cleavage of the C1-triazole bond of propiconazole, liberating 1,2,4-triazole as the major product. Six more degradation products are identified which are not included in the mammalian metabolites.
Versand/Shipping
UN3082 Environmentally hazardous substances, liquid, n.o.s., Hazard class: 9; Labels: 9-Miscellaneous hazardous material, Technical Name Required. UN3077 Environmentally hazardous substances, solid, n.o.s., Hazard class: 9; Labels: 9-Miscellaneous hazardous material, Technical Name Required.
Degradation
Photolysis of propiconazole (1) in hexane and methanolic solutions irradiated with a high-pressure mercury lamp gave a mixture of products 2-8 (Scheme 1) (Dureja et al., 1987). The major product isolated was 1,2,4- triazole (7). A monodechlorinated product (5) was formed in hexane. The dioxolane ring was cleaved in methanol under these conditions.
Sunlight irradiation on a sandy loam soil surface for 48 days degraded 80% of the applied material and a DTs0 of about 12 days on soil was derived through further rate studies. 1,2,4-Triazole (7) was the major product identified after exposing a thin layer of propiconazole, coated as a thin film, inside a Pyrex flask to sunlight for one month.
Toxicity evaluation
Propiconazole mode of action is demethylation of C-14 during ergosterol biosynthesis and leading to accumulation of C-14 methyl sterols. The biosynthesis of these ergosterols is critical to the formation of cell walls of fungi. This lack of normal sterol production slows or stops the growth of the fungus, effectively preventing further infection and/or invasion of host tissues. Therefore, propiconazole is considered to be fungistatic or growth inhibiting rather than fungicidal or killing.
Inkompatibilitäten
The triazoles are sensitive to heat, friction, and impact. Sensitivity varies with the type substitution to the triazole ring. Metal chelated and halogen substitution of the triazol ring make for a particularly heat sensitive material. Azido and nitro derivatives have been employed as high explosives. No matter the derivative these materials should be treated as explosives
Waste disposal
Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Contact a licensed disposal facility about surplus and nonrecyclable solutions. Burn in a chemical incinerator equipped with an afterburner and scrubber. Extra care must be exercised as the material in an organic solvent is highly flammable. In accordance with 40CFR165, follow recom- mendations for the disposal of pesticides and pesticide con- tainers. Containers must be disposed of properly by following package label directions or by contacting your local or federal environmental control agency, or by con- tacting your regional EPA office. Incineration or permanga- nate oxidation.

Propiconazole Upstream-Materialien And Downstream Produkte

1-((2-(2,4-Dichlorphenyl)-4-pro-pyl-1,3-dioxalan-2-yl)methyl)-1H-1,2,4-triazol Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

60207-90-1, Propiconazole Verwandte Suche:

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