(Z)-Octadec-9-enol

Bezeichnung:(Z)-Octadec-9-enol

CAS-Nr143-28-2

Englisch Name:Oleyl alcohol

CBNumberCB1353439

SummenformelC18H36O

Molgewicht268.48

MOL-Datei143-28-2.mol

Synonyma

(Z)-Octadec-9-enol

(Z)-Octadec-9-enol physikalisch-chemischer Eigenschaften

Schmelzpunkt	0-5.0 °C (lit.)
Siedepunkt	207 °C/13 mmHg (lit.)
Dichte	0.849 g/mL at 25 °C (lit.)
Dampfdruck	10.64 hPa (195 °C)
FEMA	4363 \| CIS-9-OCTADECENOL
Brechungsindex	n20/D 1.46(lit.)
Flammpunkt	>230 °F
storage temp.	-20°C
Löslichkeit	Soluble in ethanol (95%), and ether; practically insoluble in water.
Aggregatzustand	Viscous Liquid
pka	15.20±0.10(Predicted)
Farbe	Clear almost colorless to yellow
Geruch (Odor)	fatty animal
Geruchsart	fatty
Wasserlöslichkeit	Miscible with alcohol and ether. Slightly miscible with carbon tetrachloride. Immiscible with water.
Merck	14,6831
JECFA Number	1637
BRN	1723962
Stabilität	Stable. Combustible. Incompatible with strong acids, strong oxidizing agents.
LogP	7.07 at 25℃
CAS Datenbank	143-28-2(CAS DataBase Reference)
NIST chemische Informationen	Oleyl Alcohol(143-28-2)
EPA chemische Informationen	9-Octadecen-1-ol, (9Z)- (143-28-2)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	38
S-Sätze:	26-36
WGK Germany	-
RTECS-Nr.	RG4120000
TSCA	Yes
HS Code	29052990
Giftige Stoffe Daten	143-28-2(Hazardous Substances Data)
Toxizität	LD50 orally in Rabbit: > 5000 mg/kg

Gefahreninformationscode (GHS)

Oleyl alcohol Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R38:Reizt die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
Oleyl alcohol occurs as a pale yellow oily liquid that gives off acrid fumes when heated.
Chemische Eigenschaften
Colorless to light yellow liquid; fatty aroma with animal undertones.
Chemische Eigenschaften
Colourless or light yellow liquid.
Verwenden
Oleyl alcohol is used in softening and lubrication of textile fabrics, and in the production of carbon paper, stencil paper, and printing ink. It finds application in cosmetic products viz skin creams and lotions as a thickner, hair conditioners and hair coating shampoos. It is utilized as an antifoaming agent and cutting lubricant, as the precursor for the preparation of its sulfuric ester derivatives, which are used in detergents and wetting agents. It plays a vital role in various formulations for drug delivery.
Verwenden
oleyl alcohol is an emollient, solvent, viscosity-increasing agent, and carrier employed in a wide variety of cosmetic formulations including makeup, skin care, and hand and body preparations. oleyl alcohol is an unsaturated fatty alcohol found in fish oils and can also be produced synthetically. According to some sources, it is comedogenic and has a mild irritancy potential.
Verwenden
Chiefly in the manufacture of its sulfuric esters which are detergents and wetting agents, as an antifoam agent; metal cutting lubricant; in carbon paper, stencil paper, printing ink; as a plasticizer; for softening and lubricating textile fabrics; carrier for medicaments.
Definition
ChEBI: A long chain fatty alcohol that is octadecanol containing a double bond located at position 9 (the Z-geoisomer).
Vorbereitung Methode
Oleyl alcohol occurs naturally in fish oils. Synthetically, it can be prepared from butyl oleate by a Bouveault–Blanc reduction with sodium and butyl alcohol. An alternative method of manufacture is by the hydrogenation of triolein in the presence of zinc chromite.
Trademarks
Witcohol 85 (Witco); Witcohol 90 (Witco).
Aroma threshold values
Fatty-type, medium strength odor.
Allgemeine Beschreibung
Oleyl alcohol has been reported as an effective solvent for oil/water-type tacrolimus (FK506) cream formulation, useful for atopic dermatitis treatment. It was reported as diluting agent for Alamine 336. Palm oil esters derived from oleyl alcohol, have potential applications in the cosmetic and pharmaceutical industries due to the excellent wetting behavior of the esters without the oily feel.
Flammability and Explosibility
Non flammable
Pharmazeutische Anwendungen
Oleyl alcohol is mainly used in topical pharmaceutical formulations and has been used in transdermal delivery formulations.It has been utilized in the development of biodegradable injectable thermoplastic oligomers,and in aerosol formulations of insulin and albuterol.
Therapeutically, it has been suggested that oleyl alcohol may exhibit antitumor properties via transmembrane permeation.
Sicherheitsprofil
A human skin and eye irritant. Aningredient in cosmetics. When heated to decomposition itemits acrid smoke and irritating fumes.
Sicherheit(Safety)
Oleyl alcohol is mainly used in topical pharmaceutical formulations and is generally regarded as a nontoxic and nonirritant material at the levels employed as an excipient. However, contact dermatitis due to oleyl alcohol has been reported.
The results of acute oral toxicity and percutaneous studies in animals with products containing 8% oleyl alcohol indicate a very low toxicity. Formulations containing 8% or 20% oleyl alcohol administered by gastric intubation, at doses up to 10 g/kg bodyweight, caused no deaths and no toxic effects in rats.
Lager
The bulk material should be stored in a well-closed container in a cool, dry, place.
läuterung methode
Purify it by fractional crystallisation at -40o from acetone, then distil it under vacuum. [Beilstein 2 IV 2204.]
Regulatory Status
Included in the FDA Inactive Ingredients Database (topical emulsions and ointments). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

Oleyl alcohol Upstream-Materialien And Downstream Produkte

(Z)-Octadec-9-enol Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

143-28-2, Oleyl alcohol Verwandte Suche:

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