N-BOC-1,6-diaminohexane Struktur

N-BOC-1,6-diaminohexane

Bezeichnung:N-BOC-1,6-diaminohexane

CAS-Nr51857-17-1

Englisch Name:N-BOC-1,6-diaminohexane

CBNumberCB0702254

SummenformelC11H24N2O2

Molgewicht216.32

MOL-Datei51857-17-1.mol

N-BOC-1,6-diaminohexane physikalisch-chemischer Eigenschaften

Siedepunkt	106-110 °C (0.3 mmHg)
Dichte	0.965 g/mL at 20 °C(lit.)
Brechungsindex	n20/D 1.462
Flammpunkt	125 °C
storage temp.	Keep in dark place,Inert atmosphere,2-8°C
Löslichkeit	Soluble in dichloromethane and ethyl acetate.
pka	12.93±0.46(Predicted)
Aggregatzustand	Viscous Liquid
Farbe	Clear light yellow
Sensitive	Air Sensitive
BRN	2089264
InChIKey	RVZPDKXEHIRFPM-UHFFFAOYSA-N
CAS Datenbank	51857-17-1(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	C
R-Sätze:	34
S-Sätze:	26-36/37/39-45
RIDADR	UN 2735 8/PG 2
WGK Germany	3
F	10-34
HazardClass	8
PackingGroup	III
HS Code	29241900

Gefahreninformationscode (GHS)

N-BOC-1,6-diaminohexane Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R34:Verursacht Verätzungen.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
Chemische Eigenschaften
Off-White Solid
Verwenden
N-Boc-1,6-diaminohexane is used to prepare 1,3-Bis[6-(Boc-amino)hexyl]urea by reacting with carbonyl dichloride in the presence of triethylamine. Further, it is used as a reagent for the introduction of a C6-spacer.
Application
N-Boc-1,6-hexanediamine can be used as a linear hexyl spacer (C6-spacer) to synthesize:
Biodegradable poly(disulfide amine)s for gene delivery.
A multifunctional dendrimer for theranostics.
Polyamide platinum anti-cancer complexes designed to target cancer specific DNA sequences.
Self-assembled monolayers (SAMs) that resist adsorption of proteins.
[N-(6-(4-Hydroxy-6-isopropylamino-1,3,5-triazin-2-ylamino)hexyl)-5-hydroxy-1,4-naphthoquinone-3-propionamide] (JUG-HATZ), which can be used in designing electrochemical immunosensors.
synthetische
synthesis of N-BOC-1,6-diaminohexane: 1,6-Diaminohexane 3 (Fig. 1) (100 g, 0.86 mol) was dissolved in CH2Cl2 (300 ml) and cooled in an ice bath to 0–3°C. To the stirred solution 0.3 eq. di-tert-butyl bicarbonate (62.6 g, 0.29 mol) was added slowly over a period of 1 h. The reaction was allowed to warm up to r.t., and proceeded overnight. The reaction mixture was extracted with saturated aqueous NaHCO3 (50 ml, three times). The organic phases were pooled, dried, and evaporated under reduced pressure. The resulting oil was dissolved in 200 ml, 1 N HCl and extracted with ether. The aqueous phase was washed with ether, made basic to a pH of 10 with aqueous 2 N NaO3, and extracted with ethyl acetate. The organic phases were pooled, dried, and evaporated under reduced pressure. The resulting oil was dissolved in 200 ml, 1 N HCL and extracted with ether. The aqueous phase was washed with ether, made basic to a pH of 10 with aqueous 2 N NaOH, and extracted with ethyl acetate. The organic extracts were pooled, dried over Na2SO4 and evaporated to give 10.5 g of homogeneous N-BOC-1, 6- diaminohexane 2c (Fig. 1) as a yellow oil which was used without further purification.
TLC Rf 0.51; 1H NMR (CDCL3) d 4.54 (bs, 1H; NH), 3.05 1 2.62 (m, 4H; NCH2), 1.41 (m, 9H; CH3), 1.29 (m, 8H; CH2).
Evaluation of aminoalkylmethacrylate nanoparticles as colloidal drug carrier systems. Part I: synthesis of monomers, dependence of the physical properties on the polymerization methods

N-BOC-1,6-diaminohexane Upstream-Materialien And Downstream Produkte

N-BOC-1,6-diaminohexane Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

51857-17-1, N-BOC-1,6-diaminohexane Verwandte Suche:

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