Concanavalin A

Bezeichnung:Concanavalin A

CAS-Nr11028-71-0

Englisch Name:Concanavalin A

CBNumberCB0689980

SummenformelC15H24

Molgewicht0

MOL-DateiMol file

Synonyma

Concanavalin A

Concanavalin A physikalisch-chemischer Eigenschaften

Flammpunkt	39 °C
storage temp.	-20°C
Löslichkeit	PBS: 5 mg/mL, slightly hazy
Aggregatzustand	powder
Farbe	White to light yellow
Wasserlöslichkeit	Slightly soluble in water and phosfate buffered saline.
CAS Datenbank	11028-71-0

Sicherheit

Kennzeichnung gefährlicher	Xn
R-Sätze:	10-42/43-63-40-20/21/22
S-Sätze:	36-24/25-45-36/37-23-22
RIDADR	UN 1170 3/PG 3
WGK Germany	3
RTECS-Nr.	GK6890000
F	10-21
HS Code	35040090

Gefahreninformationscode (GHS)

Concanavalin A Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R10:Entzündlich.
S-Sätze Betriebsanweisung:
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
Lyophilized
Verwenden
Concanavalin A is a plant lectin that is a T-cell mitogen, and induces apoptosis in human fibroblasts.
Verwenden
Concanavalin A is a unique lectin purified from the jack bean, C. ensiformis, that selectively cross-links cell-surface glycoproteins and affects the initiation of cell agglutination, mitogenesis, and apoptosis. Concanavalin A specifically binds to α-mannose and α-galactose structures found in sugars, glycoproteins, and glycolipids and has been used in affinity chromatography purifications of various glycoproteins and cellular structures. At 20 mg/kg concanavalin A is also used to induce liver injury in experimental mouse models of autoimmune hepatitis in order to study immune regulation by macrophages and T cells. Concanavalin A is toxic to several tumor cell lines and has been reported to induce programmed cell death of cortical neurons by a mechanism similar to that of the amyloid β peptide.
Verwenden
As a reagent in analytical and preparative biochemistry; as a probe in studies of cell surface membrane dynamics and cell division.
Definition
A lectin mitogen that binds specifically to and agglutinates transforms into tumors. It binds to glucose and mannose residues in the surface.
Allgemeine Beschreibung
Concanavalin A is a protein containing only β-sheets in its structure, and belongs to the legume lectins family.
Hazard
Poison; teratogen; mutagen.
Biochem/physiol Actions
Concanavalin A is known to stimulate acute hepatic inflammation and acts as a T‐cell mitogen. It has inhibitory effect on hepatocellular carcinoma by inducing autophagy.
Lager
-20°C

Concanavalin A Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

11028-71-0, Concanavalin A Verwandte Suche:

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