5-BROMOPYRIDINE-2-CARBOXAMIDE 97%5-BROMOPICOLINAMIDE

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Warnung

• Gefahrenhinweise

  H302：Gesundheitsschädlich bei Verschlucken.

  H315：Verursacht Hautreizungen.

  H319：Verursacht schwere Augenreizung.

  H335：Kann die Atemwege reizen.

• Sicherheit

  P271：Nur im Freien oder in gut belüfteten Räumen verwenden.

  P280：Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.

  P301+P312：BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.

5-BROMOPYRIDINE-2-CARBOXAMIDE 97%5-BROMOPICOLINAMIDE Chemische Eigenschaften,Einsatz,Produktion Methoden

• Synthese

  

  30766-11-1

  

  90145-48-5

  GENERAL PROCEDURE: To a solution of 2-carboxylic acid-5-bromopyridine (200 mg, 1 mmol) in dichloromethane (5 mL) was slowly added thionyl chloride (1 mL) dropwise and a drop of N,N-dimethylformamide (DMF). The reaction mixture was heated to 80 °C and maintained for 1 hour. Upon completion of the reaction, it was cooled to room temperature, the reaction mixture was concentrated and the residue was dissolved in dichloromethane (2 mL). The resulting solution was slowly added dropwise to ammonia (3 mL) at room temperature. Subsequently, the mixture was stirred at room temperature for 1.5 hours. At the end of the reaction, the mixture was concentrated to give 5-bromopyridinecarboxamide (85 mg, 92.4% yield) as a white solid. Liquid mass spectrometry (electrospray ionization) m/z ([M+H]+) measured value 201.2; calculated value 201.0.

• Einzelnachweise

  [1] Patent: WO2014/81619, 2014, A1. Location in patent: Page/Page column 46
  [2] Journal of Medicinal Chemistry, 2018, vol. 61, # 11, p. 4860 - 4882
  [3] Patent: US2006/217387, 2006, A1. Location in patent: Page/Page column 31
  [4] Patent: WO2012/76063, 2012, A1. Location in patent: Page/Page column 39
  [5] Patent: US2013/261100, 2013, A1. Location in patent: Paragraph 0279-0280

5-BROMOPYRIDINE-2-CARBOXAMIDE 97%5-BROMOPICOLINAMIDE Upstream-Materialien And Downstream Produkte

5-BROMOPYRIDINE-2-CARBOXAMIDE 97%5-BROMOPICOLINAMIDE Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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