Pyridin-2-carboxamid

Bezeichnung:Pyridin-2-carboxamid

CAS-Nr1452-77-3

Englisch Name:PYRIDINE-2-CARBOXAMIDE

CBNumberCB6713827

SummenformelC6H6N2O

Molgewicht122.12

MOL-Datei1452-77-3.mol

Synonyma

Pyridin-2-carboxamid

Pyridin-2-carboxamid physikalisch-chemischer Eigenschaften

Schmelzpunkt	110 °C (dec.)(lit.)
Siedepunkt	143 °C / 20mmHg
Dichte	1.2236 (rough estimate)
Brechungsindex	1.5350 (estimate)
storage temp.	Inert atmosphere,Room Temperature
Löslichkeit	DMSO (Slightly), Methanol (Slightly)
pka	pK1: 2.10(+1) (20°C)
Aggregatzustand	Solid
Farbe	White to Off-White
BRN	109617
CAS Datenbank	1452-77-3(CAS DataBase Reference)
EPA chemische Informationen	2-Pyridinecarboxamide (1452-77-3)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	26-37/39
WGK Germany	3
TSCA	Yes
HS Code	29333990

Gefahreninformationscode (GHS)

PYRIDINE-2-CARBOXAMIDE Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
Chemische Eigenschaften
White to off-white solid
Verwenden
Picolinamide was used as template in preparation of molecular imprinting polymer. Picolinamide was used in a study to evaluate kinetics and mechanism of liberation of picolinamide from chromium(III)-picolinamide complexes in HClO₄.
Verwenden
A nicotinic acid derivative for prevention and treatment of cancer by activating RUNX3 gene.
Definition
ChEBI: A pyridinecarboxamide that is the monocarboxylic acid amide derivative of picolinic acid.
Biologische Aktivität
picolinamide is a poly (adp-ribose) synthetase (parp) inhibitor.parp inhibitors, a group of pharmacological inhibitors of the enzyme poly adp ribose polymerase (parp), are developed for multiple indications, especially for the treatment of cancer.
Biochem/physiol Actions
Picolinamide is potential inhibitor of poly (ADP-ribose) synthetase of nuclei from rat pancreatic islet cells. Picolinamide acts as bidentate ligand and forms complexes with lanthanide nitrates, thiocyanates and perchlorates.
in vitro
the pathway of oxidation of picolinamide by a gram-negative rod has been elucidated. results showed that under high ph conditions, whole cells could release 2,5-dihydroxypyridine into culture supernatants. moreover, sodium arsenite was able to cause whole cells to accumulate 6-hydroxypicolinate in the culture media. in addition, whole cells were found to oxidize picolinamide, without lag. it was also found that cell-free extracts could convert picolinamide into picolinate, and hydroxylate picolinate into 6-hydroxypicolinate [1].
in vivo
picolinamide was used in a previous study to evaluate the possibility that the inhibition of na+/phosphate cotransport might be associated with the inhibition of nad hydrolyzing enzymes. results showed that the overnight treatment of rats with picolinamide, administered as a single injection (4 mmol/kg), could inhibit na+/phosphate cotransport by isolated renal brush border membrane vesicles. similar to nicotinamide, the inhibition caused by picolinamide occurred in thyroparathyroidectomized rats, was specific for na+/phosphate cotransport. unlike nicotinamide, there was only a small 1.5-fold increase in renal cortical nad content after picolinamide treatment [2].
Einzelnachweise
[1] c. g. orpin,m. knight, and w. c. evans. the bacterial oxidation of picolinamide, a photolytic product of diquatbiochem j. 1972 may; 127(5): 819–831.
[2] campbell pi, al-mahrouq ha,abraham mi,kempson sa. specific inhibition of rat renal na+/phosphate cotransport by picolinamide. j pharmacol exp ther.1989 oct;251(1):188-92.

PYRIDINE-2-CARBOXAMIDE Upstream-Materialien And Downstream Produkte

Pyridin-2-carboxamid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

1452-77-3, PYRIDINE-2-CARBOXAMIDE Verwandte Suche:

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