Clotiazepam

CLOTIAZEPAM Chemische Eigenschaften,Einsatz,Produktion Methoden

• Chemische Eigenschaften

  Off-White Solid

• Originator

  Rize,Yoshitomi,Japan,1979

• Verwenden

  A thienodiazepine derivative that possesses anxiolytic, skeletal muscle relaxant anticonvulsant, sedative properties as well as contributing to siginificant increase stage 2 NREM sleep. It binds to be nzodiazepine site of the GABAA receptor where it acts as a full agonist resulting in enhanced GABA inhibitory effect at the GABAA receptor. Controlled Substance.

• Definition

  ChEBI: Clotiazepam is an organic molecular entity.

• Manufacturing Process

  To a solution of 10 g of 2-N-methylaminoacetamido-3-o-chlorobenzoyl-5-ethylthiophene in 50 ml of pyridine are added 20 ml of benzene and 1.9 g of acetic acid. The resulting mixture is refluxed with stirring for 10 hours in a flask provided with a water-removing adaptor. The reaction mixture is concentrated, and the residue is extracted with chloroform. The chloroform layer is washed with water and then with a sodium hydrogen carbonate solution, then dried over magnesium sulfate. The chloroform is distilled off under reduced pressure, and toluene is added to the residue. Thus is precipitated white crystalline-5-o-chlorophenyl-7-ethyl-1-methyl-1,2-dihydro- 3H-thieno-[2,3-e][1,4]diazepin-2-one, MP 105°C to 106°C.

• Therapeutic Function

  Tranquilizer

CLOTIAZEPAM Upstream-Materialien And Downstream Produkte

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