Chloramphenicolnatriumsuccinat

Bezeichnung:Chloramphenicolnatriumsuccinat

CAS-Nr982-57-0

Englisch Name:Chloramphenicol sodium succinate

CBNumberCB0406947

SummenformelC15H15Cl2N2O8.Na

Molgewicht445.19

MOL-Datei982-57-0.mol

Synonyma

Chloramphenicolnatriumsuccinat

Chloramphenicolnatriumsuccinat physikalisch-chemischer Eigenschaften

Schmelzpunkt	>42oC (dec.)
storage temp.	-20°C Freezer, Under inert atmosphere
Löslichkeit	H2O: soluble50mg/mL
Aggregatzustand	solid
Farbe	White to Off-White
InChIKey	RPLOPBHEZLFENN-HTMVYDOJSA-M
CAS Datenbank	982-57-0(CAS DataBase Reference)
EPA chemische Informationen	Chloramphenicol sodium succinate (982-57-0)

Sicherheit

Kennzeichnung gefährlicher	Xn
R-Sätze:	40
S-Sätze:	22-36
WGK Germany	3
RTECS-Nr.	AB6905000

Gefahreninformationscode (GHS)

Chloramphenicol sodium succinate Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R40:Verdacht auf krebserzeugende Wirkung.
S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
White or yellowish-white powder, hygroscopic
Verwenden
antibacterial, antirickettsial, inhibits protein synthesis
Verwenden
Chloramphenicol Succinate Sodium is a derivative of Chloramphenicol (C325030) which are broad spectrum antibiotic obtained from cultures of the soil bacterium Streptomyces venezuelae. It has a broad spectrum of activity against Gram-positive and gram-negative bacteria. Antibacterial; antirickettsial.
Verwenden
Chloramphenicol succinate sodium is the salt prepared from chloramphenicol succinate using the free carboxylic acid of the succinate which ionises and readily forms in weakly sodium hydroxide solutions. The sodium salt is the preferred formulation for pharmaceutical applications, providing a more readily soluble product. Chloramphenicol succinate is significantly less active than chloramphenicol but acts as a prodrug, forming chloramphenicol in the presence of succinate dehydrogenase.
Allgemeine Beschreibung
Chloramphenicol sodium succinate is the water-solublesodium salt of the hemisuccinate ester of chloramphenicol.Because of the low solubility of chloramphenicol, the sodiumsuccinate is preferred for intravenous administration. Theavailability of chloramphenicol from the ester followingintravenous administration is estimated to be 70% to 75%; theremainder is excreted unchanged. Poor availability ofthe active form from the ester following intramuscular injectionprecludes attaining effective plasma levels of the antibioticby this route. Orally administered chloramphenicol orits palmitate ester actually gives higher plasma levels of theactive antibiotic than does intravenously administered chloramphenicolsodium succinate. Nonetheless, effectiveconcentrations are achieved by either route.
Allgemeine Beschreibung
White powder.
Air & Water Reaktionen
Freely soluble in water.
Brandgefahr
Flash point data for Chloramphenicol sodium succinate are not available, but Chloramphenicol sodium succinate is probably combustible.

Chloramphenicolnatriumsuccinat Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

982-57-0, Chloramphenicol sodium succinate Verwandte Suche:

Send Inquriy