5-HYDROXYINDOLE-3-ACETIC ACID Struktur

5-Hydroxyindol-3-ylessigsure

Bezeichnung:5-Hydroxyindol-3-ylessigsure

CAS-Nr54-16-0

Englisch Name:5-HYDROXYINDOLE-3-ACETIC ACID

CBNumberCB0362913

SummenformelC10H9NO3

Molgewicht191.18

MOL-Datei54-16-0.mol

Synonyma

5-Hydroxyindol-3-ylessigsure

5-Hydroxyindol-3-ylessigsure physikalisch-chemischer Eigenschaften

Schmelzpunkt	161-164 °C (dec.) (lit.)
Siedepunkt	326.92°C (rough estimate)
Dichte	1.2722 (rough estimate)
Brechungsindex	1.5310 (estimate)
storage temp.	-20°C
Löslichkeit	Soluble in ethanol (50 mg/ml).
pka	4.54±0.30(Predicted)
Aggregatzustand	crystalline
Farbe	off-white to purple
Sensitive	Light Sensitive
BRN	168797
Stabilität	Air Sensitive, Light Sensitive
InChIKey	DUUGKQCEGZLZNO-UHFFFAOYSA-N
CAS Datenbank	54-16-0

Sicherheit

S-Sätze:	22-24/25
WGK Germany	3
RTECS-Nr.	NL3650000
F	8-10-23
HS Code	29339980

Gefahreninformationscode (GHS)

5-HYDROXYINDOLE-3-ACETIC ACID Chemische Eigenschaften,Einsatz,Produktion Methoden

S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
Beschreibung
5-hydroxy Indole-3-acetic acid (5-HIAA) is the primary metabolite of serotonin (5-HT; ). It is formed when 5-HT is metabolized by monamine oxidase and aldehyde dehydrogenase in the liver. 5-HIAA is excreted in urine and has been used as a biomarker for detection of neuroendocrine tumors and an internal standard for the quantification of serotonin metabolism in rat brain using mass spectrometry. 5-HIAA has also been associated with autism, insomnia, and chronic migraine.
Chemische Eigenschaften
beige crystalline powder
Verwenden
5-Hydroxyindole-3-acetic acid is a major serotonin metabolite.
Verwenden
5-Hydroxyindole-3-acetic acid is an impurity of chlorpheniramine (C424300), an antihistaminic agent.
Definition
ChEBI: A member of the class of indole-3-acetic acids that is indole-3-acetic acid substituted by a hydroxy group at C-5.
Allgemeine Beschreibung
5-Hydroxyindole-3-acetic acid (5-HIAA) is the catabolic end product of serotonin pathway. 5-HIAA is present in body fluids like cerebrospinal fluid (CSF), blood and urine. The expression levels of 5-HIAA is different among the normal and cancer patients. Sepiapterin reductase deficiency results in low level of 5-HIAA in CSF. 5-HIAA level is low in CSF in patients with bipolar 1 disorder with childhood attention-deficit hyperactivity disorder (ADHD).
Mechanism of action
The primary product of the metabolism of serotonin. Formed by the oxidative deamination of serotonin by monoamine oxidase, presumably the A isozyme, 5-HIAA is subsequently cleared by an active transport mechanism. Unlike serotonin, 5-HIAA is not a neurotransmitter and thus its formation contributes to the termination of the synaptic actions of serotonin. Inhibition of monoamine oxidase activity enhances and prolongs the actions of serotonin.

5-Hydroxyindol-3-ylessigsure Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

54-16-0, 5-HYDROXYINDOLE-3-ACETIC ACID Verwandte Suche:

Send Inquriy