1-Methyl-1H-indol-3-carbaldehyd

Bezeichnung:1-Methyl-1H-indol-3-carbaldehyd

CAS-Nr19012-03-4

Englisch Name:1-Methylindole-3-carboxaldehyde

CBNumberCB1201057

SummenformelC10H9NO

Molgewicht159.18

MOL-Datei19012-03-4.mol

Synonyma

1-Methyl-1H-indol-3-carbaldehyd

1-Methyl-1H-indol-3-carbaldehyd physikalisch-chemischer Eigenschaften

Schmelzpunkt	70-72 °C (lit.)
Siedepunkt	186-189 °C(Press: 3-4 Torr)
Dichte	1.10±0.1 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
Aggregatzustand	Crystalline Powder and Chunks
Farbe	Light yellow to orange or brown
Wasserlöslichkeit	Insoluble in water.
Sensitive	Air Sensitive
BRN	121302
CAS Datenbank	19012-03-4(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	26-37/39
WGK Germany	3
HazardClass	IRRITANT
HS Code	29339900

Gefahreninformationscode (GHS)

1-Methylindole-3-carboxaldehyde Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
Chemische Eigenschaften
light yellow to orange or brown crystalline powder
Verwenden
1-Methylindole-3-carboxaldehyde is used as a reactant for preparation of nitroolefins and β-nitroalcohols via microwave- or ultrasound-assisted Henry reactions, reactant for synthesis of quinolinones via three-component Ugi reaction, reactant for synthesis of α-ketoamides as inhibitors of Dengue virus protease with antiviral activity in cell-culture, reactant for preparation of thiazolopyrimidinones as inhibitors of Bcl-2 proteins, reactant for preparation of vinylindoles via Peterson olefination or olefination with Nysted reagent, reactant for preparation of indolyl alkenes from microwave-enhanced Knoevenagel condensation as antibacterial agents 1-Methylindole-3-carboxaldehyde may be used in the synthesis of (Z)-3-(1-methyl-1H-indol-3-yl)-2-(thiophen-3-yl)acrylonitrile, via base-catalyzed condensation with thiophene-3-acetonitrile. It was also used in the preparation of monomer, required for the synthesis of poly(3-vinyl-1-methylindole).
Verwenden
Reactant for preparation of nitroolefins and β-nitroalcohols via microwave- or ultrasound-assisted Henry reactions Reactant for synthesis of quinolinones via three-component Ugi reaction Reactant for synthesis of α-ketoamides as inhibitors of Dengue virus protease with antiviral activity in cell-culture Reactant for preparation of thiazolopyrimidinones as inhibitors of Bcl-2 proteins Reactant for preparation of vinylindoles via Peterson olefination or olefination with Nysted reagent Reactant for preparation of indolyl alkenes from microwave-enhanced Knoevenagel condensation as antibacterial agents.
Synthesis Reference(s)
Tetrahedron, 49, p. 4015, 1993 DOI: 10.1016/S0040-4020(01)89915-4
Synthesis, p. 396, 1987 DOI: 10.1055/s-1987-27960
Allgemeine Beschreibung
1-Methylindole-3-carboxaldehyde is a heterocyclic indole aldehyde. 1-Methylindole-3-carboxaldehyde on condensation with 2-hydroxybenzohydrazide yields Schiff base.

1-Methylindole-3-carboxaldehyde Upstream-Materialien And Downstream Produkte

1-Methyl-1H-indol-3-carbaldehyd Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

19012-03-4, 1-Methylindole-3-carboxaldehyde Verwandte Suche:

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