3β-Hydroxyandrost-5-en-17-onacetat

Bezeichnung:3β-Hydroxyandrost-5-en-17-onacetat

CAS-Nr853-23-6

Englisch Name:Dehydroepiandrosterone acetate

CBNumberCB0247928

SummenformelC21H30O3

Molgewicht330.47

MOL-Datei853-23-6.mol

Synonyma

3β-Hydroxyandrost-5-en-17-onacetat

3β-Hydroxyandrost-5-en-17-onacetat physikalisch-chemischer Eigenschaften

Schmelzpunkt	168-170 °C(lit.)
Siedepunkt	407.89°C (rough estimate)
Dichte	1.0998 (rough estimate)
Dampfdruck	0Pa at 20℃
Brechungsindex	1.5192 (estimate)
storage temp.	Refrigerator
Löslichkeit	Chloroform, DMSO (Slightly), Methanol (Slightly)
Aggregatzustand	Solid
Farbe	White to Off-White
Optische Rotation	[α]20/D +2.4°, c = 2 in ethanol
Wasserlöslichkeit	11.5mg/L(temperature not stated)
InChI	InChI=1/C21H30O3/c1-13(22)24-15-8-10-20(2)14(12-15)4-5-16-17-6-7-19(23)21(17,3)11-9-18(16)20/h4,15-18H,5-12H2,1-3H3/t15-,16-,17-,18-,20-,21-/s3
InChIKey	NCMZQTLCXHGLOK-KJBVPOJVSA-N
SMILES	C[C@]12CC[C@H](OC(=O)C)CC1=CC[C@@]1([H])[C@]3([H])CCC(=O)[C@@]3(C)CC[C@]21[H] \|&1:1,4,13,15,21,25,r\|
LogP	5.1 at 20℃
CAS Datenbank	853-23-6

Sicherheit

S-Sätze:	22-24/25
WGK Germany	3
RTECS-Nr.	BV8396810

Gefahreninformationscode (GHS)

Dehydroepiandrosterone acetate Chemische Eigenschaften,Einsatz,Produktion Methoden

S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
Chemische Eigenschaften
Off-White Solid
Verwenden
A metabolite of Dehydroepiandrosterone. This mammalian pro-hormone promotes brain and immune function
Verwenden
Menopausal syndrome
Definition
ChEBI: Prasterone acetate is a steroid ester.
Application
Dehydroepiandrosterone acetate (CAS No: 853-23-6, abbreviated as DHEA acetate) is an important pharmaceutical intermediate. It can be used as a raw material to produce testosterone, methyl testosterone, estradiol, and estriol. Recently, with the development of the pharmaceutical industry, more and more applications for DHEA acetate have been exploited[1].
Flammability and Explosibility
Not classified
Biologische Aktivität
Dehydroepiandrosterone acetate (DHEA, Androstenolone) is a kind of dehydroepiandrosterone derivatives. DHEA is an endogenous steroid hormone, which is considered to be a natural product/dietary supplement with many proposed benefits to humans.
in vivo
Dehydroisoandrosterone implants increases aggression in a laboratory-based simulated territorial intrusion. Brains of Dehydroisoandrosterone-implanted birds show higher aromatase mRNA expression in the preoptic area (POA) and higher androgen receptor mRNA expression in the periventricular nucleus of the medial striatum (pvMSt) and ventromedial nucleus of the hypothalamus (VMH). The Dehydroisoandrosterone-induced increases in aromatase expression in the POA and androgen receptor expression in the pvMSt are consistent with previously reported seasonal increases in these markers associated with naturally elevated Dehydroisoandrosterone levels. Dehydroisoandrosterone supplementation (10.2 mg/kg) alone significantly increases mice body weight (BW), muscle weight, testosterone level, and glycogen contents (liver and muscle) when compared with SC group.
Einzelnachweise
[1] Chao Cheng. “Solubility determination and thermodynamic models for dehydroepiandrosterone acetate in mixed solvents of (ethyl acetate + methanol), (ethyl acetate + ethanol) and (ethyl acetate + isopropanol).” Journal of Chemical Thermodynamics 101 (2016): Pages 372-379.

Dehydroepiandrosterone acetate Upstream-Materialien And Downstream Produkte

3β-Hydroxyandrost-5-en-17-onacetat Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

853-23-6, Dehydroepiandrosterone acetate Verwandte Suche:

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