1,5-Difluoro-3-methoxy-2-nitro-benzene

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Warnung

• Gefahrenhinweise

  H302：Gesundheitsschädlich bei Verschlucken.

  H315：Verursacht Hautreizungen.

  H319：Verursacht schwere Augenreizung.

  H335：Kann die Atemwege reizen.

• Sicherheit

  P261：Einatmen von Staub vermeiden.

  P305+P351+P338：BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

1,5-Difluoro-3-methoxy-2-nitro-benzene Chemische Eigenschaften,Einsatz,Produktion Methoden

• Synthese

  

  93343-10-3

  

  66684-61-5

  1. 3,5-difluoroanisole (30 g, 208 mmol) was dissolved in 260 mL of dichloromethane at 0 °C. 2. Fuming nitric acid (60 mL) at a concentration of greater than 90% was added slowly and dropwise to the above solution. 3. The reaction mixture was kept stirred at 0 °C for 3 h. 4. After completion of the reaction, the reaction mixture was washed with water. 5. The aqueous phase was extracted with dichloromethane. 6. The organic phases were combined and washed with brine, followed by drying with magnesium sulfate.7. The dried organic phase was concentrated on a rotary evaporator.8. The residue was recrystallized by solvent mixing of hexane and ethyl acetate to afford 28.5 g (72% yield) of 1,5-difluoro-3-methoxy-2-nitrobenzene, the product being an off-white powder.1H NMR (400 MHz, DMSO) δ ppm: 7.20 (m, 2H), 3.91 (s, 3H).

• Einzelnachweise

  [1] Patent: US2009/143367, 2009, A1. Location in patent: Page/Page column 30
  [2] Journal of Medicinal Chemistry, 2011, vol. 54, # 21, p. 7621 - 7638

1,5-Difluoro-3-methoxy-2-nitro-benzene Upstream-Materialien And Downstream Produkte

1,5-Difluoro-3-methoxy-2-nitro-benzene Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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