3',5'-Dichloro-2,2,2-trifluoroacetophenone

Bezeichnung:3',5'-Dichloro-2,2,2-trifluoroacetophenone

CAS-Nr130336-16-2

Englisch Name:3',5'-Dichloro-2,2,2-trifluoroacetophenone

CBNumberCB0206550

SummenformelC8H3Cl2F3O

Molgewicht243.01

MOL-Datei130336-16-2.mol

3',5'-Dichloro-2,2,2-trifluoroacetophenone physikalisch-chemischer Eigenschaften

Siedepunkt	265℃
Dichte	1.506
Brechungsindex	1.4980 to 1.5020
Flammpunkt	114℃
storage temp.	Sealed in dry,Room Temperature
Löslichkeit	Acetonitrile (Slightly), Chloroform (Slightly), Methanol (Slightly)
Aggregatzustand	Oil
Farbe	Colourless
InChI	InChI=1S/C8H3Cl2F3O/c9-5-1-4(2-6(10)3-5)7(14)8(11,12)13/h1-3H
InChIKey	DZDSQRPDUCSOQV-UHFFFAOYSA-N
SMILES	C(=O)(C1=CC(Cl)=CC(Cl)=C1)C(F)(F)F
CAS Datenbank	130336-16-2

Sicherheit

R-Sätze:	36/37/38
S-Sätze:	26-36/37/39
HS Code	2914790090

Gefahreninformationscode (GHS)

3',5'-Dichloro-2,2,2-trifluoroacetophenone Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
Verwenden
3'',5''-Dichloro-2,2,2-trifluoroacetophenone is a reagent used for enantioselective preparation of benzazephinoindoles bearing trifluoromethylated quaternary stereocenters catalyzed by chiral spirocyclic phosphoric acids
Synthese

19752-55-7

407-25-0

130336-16-2

Under nitrogen protection, tert-butyllithium (1.3 M in pentane, 17.8 mL, 23.2 mmol) was slowly added dropwise to a solution of 3,5-dichloro-1-bromobenzene (5.0 g, 22.1 mmol) in tetrahydrofuran (50 mL) over a period of 30 min, followed by continuing the reaction for 2 h at -78 °C. Upon completion of the reaction, trifluoroacetic anhydride (2.56 g, 12.2 mmol) was slowly added dropwise to the reaction mixture and stirring was continued for 2 hours at -78 °C. The cooling bath was removed and the reaction mixture was allowed to warm slowly to room temperature and stirring was continued at room temperature for 2.5 hours. When the reaction was terminated, saturated ammonium chloride solution (50 mL) was added. The reaction mixture was extracted with ether (3 x 50 mL) and the organic phases were combined and washed with saturated brine (20 mL x 2). The organic phase was separated, dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure, and purified by distillation under reduced pressure to give the colorless transparent liquid 3',5'-dichloro-2,2,2-trifluoroacetophenone (2.58 g, 48% yield).
Einzelnachweise
[1] Patent: CN107353189, 2017, A. Location in patent: Paragraph 0019; 0023
[2] Bulletin of the Chemical Society of Japan, 1997, vol. 70, # 12, p. 3081 - 3090

3',5'-Dichloro-2,2,2-trifluoroacetophenone Upstream-Materialien And Downstream Produkte

3',5'-Dichloro-2,2,2-trifluoroacetophenone Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

130336-16-2, 3',5'-Dichloro-2,2,2-trifluoroacetophenone Verwandte Suche:

Send Inquriy