Chalkon

Bezeichnung:Chalkon

CAS-Nr94-41-7

Englisch Name:Chalcone

CBNumberCB0746254

SummenformelC15H12O

Molgewicht208.26

MOL-Datei94-41-7.mol

Synonyma

Chalkon

Chalkon physikalisch-chemischer Eigenschaften

Schmelzpunkt	55-59 °C
Siedepunkt	208 °C25 mm Hg(lit.)
Dichte	d462 1.0712
Brechungsindex	nD62 1.6458
Flammpunkt	>230 °F
storage temp.	Sealed in dry,Room Temperature
Löslichkeit	dioxane: soluble1g/10 mL, clear, colorless
Aggregatzustand	Granular Powder
Farbe	Yellow
Merck	14,2037
BRN	1210466
LogP	3.080
CAS Datenbank	94-41-7(CAS DataBase Reference)
EPA chemische Informationen	2-Propen-1-one, 1,3-diphenyl- (94-41-7)

Sicherheit

Kennzeichnung gefährlicher	Xn,Xi
R-Sätze:	22-36/37
S-Sätze:	22-36/37/39-45
WGK Germany	3
RTECS-Nr.	UD5576750
HS Code	29143900

Gefahreninformationscode (GHS)

Chalcone Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
R36/37:Reizt die Augen und die Atmungsorgane.
S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
Beschreibung
Chalcone is the organic compound C6H5C(O)CH=CHC6H5. It is an α,β-unsaturated ketone. A variety of important biological compounds are known collectively as chalcones or chalconoids.They show antibacterial, antifungal, antitumor and anti-inflammatory properties. They are also intermediates in the biosynthesis of flavonoids, which are substances widespread in plants and with an array of biological activities. Chalcones are also intermediates in the Auwers synthesis of flavones.
Chemische Eigenschaften
light yellow powder
Verwenden
Chalcone is used in the preparation of pharmacologically-interesting heterocyclic systems like pyrazolines and pyrimidines. It also inhibits the proliferation of human breast cancer cell lines, MCF-7 and MDA-MB-231 by inducing apoptosis and blocking cell cycle progression in the G2/M phase.
Verwenden
1,3-Diphenyl-2-propenone was used in the preparation of pharmacologically-interesting heterocyclic systems like pyrazolines and pyrimidines.
synthetische
Chalcone is an aromatic ketone that forms the central core for a variety of important biological compounds, which are known collectively as chalcones.
Chalcones can be prepared by an aldol condensation between a benzaldehyde and an acetophenone in the presence of sodium hydroxide as a catalyst.

This reaction has been found to work without any solvent at all - a solid-state reaction. The reaction between substituted benzaldehydes and acetophenones has been used to demonstrate green chemistry in undergraduate chemistry education.In a study investigating green chemistry synthesis, chalcones were also synthesized from the same starting materials in high temperature water (200 to 350 °C).
Definition
ChEBI: A member of the class of chalcones that is acetophenone in which one of the methyl hydrogens has been replaced by a benzylidene group.
Biologische Aktivität
1,3-Diphenyl-2-propenone (chalcone) inhibits the proliferation of human breast cancer cell lines, MCF-7 and MDA-MB-231 by inducing apoptosis and blocking cell cycle progression in the G2/M phase. It is an inhibitor of Plasmodium falciparum cyclin-dependent protein kinases.
Biochem/physiol Actions
1,3-Diphenyl-2-propenone (chalcone) inhibits the proliferation of human breast cancer cell lines, MCF-7 and MDA-MB-231 by inducing apoptosis and blocking cell cycle progression in the G2/M phase. It is an inhibitor of Plasmodium falciparum cyclin-dependent protein kinases.
Sicherheitsprofil
Poison by intravenous route. See also KETONES. When heated to decomposition it emits acrid smoke and irritating fumes.
läuterung methode
Crystallise it from EtOH by warming to 50o (about 5mL/g), iso-octane, or toluene/pet ether, or recrystallise it from MeOH, and then twice from hexane. SKIN IRRITANT. [Beilstein 7 IV 1658.]

Chalcone Upstream-Materialien And Downstream Produkte

Chalkon Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

94-41-7, Chalcone Verwandte Suche:

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