[3aR-(3aα,5β,8aβ,9aα)]-3a,5,6,7,8,8a,9,9a-Octahydro-5,8a-dimethyl-3-methylennaphtho[2,3-b]furan-2(3H)-on

Bezeichnung:[3aR-(3aα,5β,8aβ,9aα)]-3a,5,6,7,8,8a,9,9a-Octahydro-5,8a-dimethyl-3-methylennaphtho[2,3-b]furan-2(3H)-on

CAS-Nr546-43-0

Englisch Name:Alantolactone

CBNumberCB0194433

SummenformelC15H20O2

Molgewicht232.32

MOL-Datei546-43-0.mol

Synonyma

[3aR-(3aα,5β,8aβ,9aα)]-3a,5,6,7,8,8a,9,9a-Octahydro-5,8a-dimethyl-3-methylennaphtho[2,3-b]furan-2(3H)-on

[3aR-(3aα,5β,8aβ,9aα)]-3a,5,6,7,8,8a,9,9a-Octahydro-5,8a-dimethyl-3-methylennaphtho[2,3-b]furan-2(3H)-on physikalisch-chemischer Eigenschaften

Schmelzpunkt	78-79 C
Siedepunkt	275 C
alpha	D +175° (chloroform)
Dichte	1.0610 (rough estimate)
Brechungsindex	1.4360 (estimate)
storage temp.	-20°C
Löslichkeit	DMSO: soluble15mg/mL (clear solution)
Aggregatzustand	powder
Farbe	white to beige
LogP	3.380
CAS Datenbank	546-43-0(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38-43
S-Sätze:	26-36-36/37-24/25
WGK Germany	3
HS Code	29322090

Gefahreninformationscode (GHS)

Alantolactone Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
The allergen eudesmanolide sesquiterpene lactone was isolated from elecampane (Inula helenium L.). With dehydrocostuslactone and costunolide, it is a component of the (sesquiterpene) lactone-mix, used to detect sensitization to Compositae.
Chemische Eigenschaften
Crystalline powder
Verwenden
Alantolactone has been used:
- in cell viability assay
- to examine the percentage of multicentrosomal mitosis in low and high passage human embryonic stem cells (hESC)
- in assessment of degranulation
Verwenden
anthelmintic, antibacterial, antineoplastic
Verwenden
Alantolactone is sesquiterpene lactone that possesses anti-inflammatory property. Alantolactone have been studied to be developed as a novel agent against human liver cancer.
Definition
ChEBI: A sesquiterpene lactone that is 3a,5,6,7,8,8a,9,9a-octahydronaphtho[2,3-b]furan-2-one bearing two methyl substituents at positions 5 and 8a as well as a methylidene substituent at position 3.
Allgemeine Beschreibung
This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG
Biochem/physiol Actions
Alantolactone is a sesquiterpene lactone disrupts the Cripto-1/ActRII complexes, resulting in an induction of activin/SMAD3 signaling. Alantolactone inhibits proliferation in cancer cells with no affect on normal cells.
Kontakt-Allergie
The allergen eudesmanolide sesquiterpene lactone was isolated from elecampane (Inula helenium L.). With dehydrocostuslactone and costunolide, it is a component of the (sesquiterpene) lactone mix used to detect sensitization to Compositae-Asteraceae.
Lager
Store at -20°C

[3aR-(3aα,5β,8aβ,9aα)]-3a,5,6,7,8,8a,9,9a-Octahydro-5,8a-dimethyl-3-methylennaphtho[2,3-b]furan-2(3H)-on Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

546-43-0, Alantolactone Verwandte Suche:

Send Inquriy