2-Bromo-5-fluoroaniline

Bezeichnung:2-Bromo-5-fluoroaniline

CAS-Nr1003-99-2

Englisch Name:2-Bromo-5-fluoroaniline

CBNumberCB0184425

SummenformelC6H5BrFN

Molgewicht190.01

MOL-Datei1003-99-2.mol

2-Bromo-5-fluoroaniline physikalisch-chemischer Eigenschaften

Schmelzpunkt	43-47 °C (lit.)
Siedepunkt	154 °C / 23mmHg
Dichte	1.694±0.06 g/cm3(Predicted)
Flammpunkt	>230 °F
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
Aggregatzustand	powder to crystal
pka	1.52±0.10(Predicted)
Farbe	White to Light yellow to Dark green
InChI	InChI=1S/C6H5BrFN/c7-5-2-1-4(8)3-6(5)9/h1-3H,9H2
InChIKey	FWTXFEKVHSFTDQ-UHFFFAOYSA-N
SMILES	C1(N)=CC(F)=CC=C1Br
CAS Datenbank	1003-99-2(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xi,T
R-Sätze:	36/37/38
S-Sätze:	26-36
RIDADR	UN2811
WGK Germany	3
Hazard Note	Toxic
HazardClass	6.1
PackingGroup	III
HS Code	29214200

Gefahreninformationscode (GHS)

2-Bromo-5-fluoroaniline Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
2-bromo-5-fluoroaniline: a intermediate of antitumor drug.
2-bromo-5-fluoroaniline is the intermediate of antitumor drug Phortress, phortress is the benzothiazoles CYP1A1 antitumor drugs targeting by Univ Nottingham UK invention, solution becomes lipophilic compound 5F2O3(10 in the sensitive cells but Phortress enters), the latter is as potential aromatic hydrocarbon receptor (AhR) agonist, induce CYP1A1 to express, CYP1A1 metabolism through expressing produces and has high electrophilic active substance again, finally causes DNA damage and apoptosis. The method that, at present, synthetic 2-bromo-5-fluoronitrobenzene prepares 2-bromo-5-fluoroaniline is divided into two large classes:
The one: adopt a chemical reduction method, utilizing the chemical reducing agent reductase 2-bromo-5-fluoronitrobenzenes such as protochloride glass putty, iron powder, vat powder, hydrazine, and sodium borohydride (potassium), which is 2-bromo-5-fluoroaniline.
The 2nd: adopt hydro-reduction. What we do more often both at home and abroad at present is chloride or the catalytic hydrogenation of fluorine-containing arylamine, and the brominated less report of arylamine hydrogenation mainly is easily by hydrogenolysis because of bromine.
Chemische Eigenschaften
Yellow to brown crystalline powder
Verwenden
2-Bromo-5-fluoroaniline may be used to synthesize:
- orthobromothiobenzanilide of 5-fluoronitrobenzothiazole
- 2-bromo-5-fluorobenzo[¹⁴C]nitrile
- [3-¹⁴C]-5-fluoro-1,3-dihydro-1-hydroxy-2,1-benzoxaborole
- 2-bromo-5-fluoro-phenyl)-(2-methoxy-6-pentadecyl-benzyl)amine
Synthese
A preparation method of 2-Bromo-5-fluoroaniline is as follows: methanol, 2-bromo-5-fluoronitrobenzene, W-4 type Raney nickel and bromine inhibitor are put into a hydrogenation kettle to carry out hydrogenation reaction. After the reaction is completed, the reaction solution is filtered under nitrogen protection. The filtered filtrate is then distilled under reduced pressure to remove methanol, and n-hexane is added. Then, the product is washed with process water, and after washing, the product is allowed to stand and separate. Then, the organic phase is cooled and crystallized, an off-white to brownish-yellow solid is precipitated, and a wet product is obtained by suction filtration. The wet product is dried to obtain the finished product 2-Bromo-5-fluoroaniline.

2-Bromo-5-fluoroaniline Upstream-Materialien And Downstream Produkte

2-Bromo-5-fluoroaniline Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

1003-99-2, 2-Bromo-5-fluoroaniline Verwandte Suche:

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