Methylmercaptoacetat

Bezeichnung:Methylmercaptoacetat

CAS-Nr2365-48-2

Englisch Name:Methyl thioglycolate

CBNumberCB0165491

SummenformelC3H6O2S

Molgewicht106.14

MOL-Datei2365-48-2.mol

Synonyma

Methylmercaptoacetat

Methylmercaptoacetat physikalisch-chemischer Eigenschaften

Schmelzpunkt	-24 °C
Siedepunkt	42-43 °C/10 mmHg (lit.)
Dichte	1.187 g/mL at 25 °C (lit.)
Brechungsindex	n20/D 1.466(lit.)
Flammpunkt	86 °F
storage temp.	Store below +30°C.
Löslichkeit	40g/l
pka	8.04±0.10(Predicted)
Aggregatzustand	Liquid
Farbe	Clear colorless
Geruch (Odor)	Strong, unpleasant, garlic-like
Wasserlöslichkeit	40 g/L (20 ºC)
Sensitive	Air Sensitive
BRN	506259
Henry's Law Constant	1.6×10⁰ mol/(m³Pa) at 25℃, HSDB (2015)
Kosmetik-Inhaltsstoffe Funktionen	HAIR WAVING OR STRAIGHTENING
Erinnerung an die inhaltsstoffe	Methyl thioglycolate (2365-48-2)
InChI	1S/C3H6O2S/c1-5-3(4)2-6/h6H,2H2,1H3
InChIKey	MKIJJIMOAABWGF-UHFFFAOYSA-N
SMILES	COC(=O)CS
CAS Datenbank	2365-48-2(CAS DataBase Reference)
NIST chemische Informationen	Acetic acid, mercapto-, methyl ester(2365-48-2)
EPA chemische Informationen	Acetic acid, mercapto-, methyl ester (2365-48-2)

Sicherheit

Kennzeichnung gefährlicher	Xn,T
R-Sätze:	10-20/22-36/37/38-25
S-Sätze:	26-36/37-45-36/37/39-28A
RIDADR	UN 1992 3/PG 3
WGK Germany	1
RTECS-Nr.	AI7350000
TSCA	TSCA listed
HazardClass	3
PackingGroup	III
HS Code	29309070
Speicherklasse	3 - Flammable liquids
Hazard Classifications	Acute Tox. 3 Oral Acute Tox. 4 Inhalation Eye Irrit. 2 Flam. Liq. 3 Skin Irrit. 2 STOT SE 3
Giftige Stoffe Daten	2365-48-2(Hazardous Substances Data)
Toxizität	mouse,LD50,intraperitoneal,100mg/kg (100mg/kg),National Technical Information Service. Vol. AD277-689,

Gefahreninformationscode (GHS)

Methyl thioglycolate Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R10:Entzündlich.
R20/22:Gesundheitsschädlich beim Einatmen und Verschlucken.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R25:Giftig beim Verschlucken.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
Chemische Eigenschaften
CLEAR COLOURLESS LIQUID
Verwenden
Methyl thioglycolate was used in the preparation of 3-carbomethoxy-4- oxotetrahydrothiopyran, 2- and 4-carbomethoxy-3-oxotetrahydrothiophene. It is used to prepare methyl thioglycolate and aminoethanethiol conjugated gold nanorods.
Verwenden
Methyl Thioglycolate is an derivative of Thioglycolic Acid (T350760), an organic compound containing both a thiol and a carboxylic acid functional groups. Thioglycolic Acid and its derivatives are oft en used in organic synthesis as a nucleophile in thioglycolysis reactions and is also used as a S transfer agent for sulfonyl chloride synthesis. Methyl Thioglycolate have been studied for the its inf luence on neocarzinostatin activation and expression of DNA damage.
Vorbereitung Methode
Adding thioglycollic acid with purity of between 70.0 and 96.0 percent and methanol with purity of between 95.0 and 99.9 percent into a reaction device according to the molar ratio of 1:1.3-4.0; subsequently, adding an activating agent into the reaction device, stirring and heating for reaction; and after the reaction is finished, carrying out separatory distillation on reaction products to obtain the methyl thioglycolate. The activating agent is a p-toluenesulfonic acid methanol solution with a mass concentration of between 20 and 30 percent, and the use amount is 0.5 to 1.0 percent of the total mass of relative input materials.
Application
Methyl thioglycolate is a chemical compound that is used in the pharmaceutical industry as an intermediate. It has been used to synthesize anti-inflammatory drugs, such as aspirin and ibuprofen, and also for the treatment of autoimmune diseases. Methyl thioglycolate binds to amino acids on the surface of bacteria, which prevents them from functioning properly. This binding causes the cells to stop growing and die.
Definition
Methyl thioglycolate are widely used in free-radical photoinitiated polymerization reactions. In particular, the use of methyl thioglycolate (MTG), CH3OC(O)CH2SH, results in greater photopolymerization reaction rates, attributed to a weakening of the sulfur–hydrogen bond by hydrogen bonding of the thiol group. MTG constitutes the smaller exponent of the series of CH3OC(O)(CH2)nSH compounds, reported as intermediated in the organic sulfur cycle in marine environments, produced by marine phytoplankton.
Allgemeine Beschreibung
Methyl thioglycolate reacts with nonprotein component of the antitumor antibiotic neocarzinostatin to form 1:1 adduct. It reacts with isothiocyanate to form Rhodanine.
reaction suitability
reagent type: ligand
reaction type: [1,2]-Wittig Rearrangement

Methyl thioglycolate Upstream-Materialien And Downstream Produkte

Methylmercaptoacetat Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

2365-48-2, Methyl thioglycolate Verwandte Suche:

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