Methyl-3-mercaptopropionat

Bezeichnung:Methyl-3-mercaptopropionat

CAS-Nr2935-90-2

Englisch Name:Methyl 3-mercaptopropionate

CBNumberCB3262607

SummenformelC4H8O2S

Molgewicht120.17

MOL-Datei2935-90-2.mol

Synonyma

Methyl-3-mercaptopropionat

Methyl-3-mercaptopropionat physikalisch-chemischer Eigenschaften

Schmelzpunkt	38 °C(Solv: ethyl ether (60-29-7); ligroine (8032-32-4))
Siedepunkt	54-55 °C/14 mmHg (lit.)
Dichte	1.085 g/mL at 25 °C (lit.)
Brechungsindex	n20/D 1.464(lit.)
Flammpunkt	140 °F
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
Löslichkeit	soluble in Chloroform, Ethyl Acetate
pka	9.17±0.25(Predicted)
Aggregatzustand	Liquid
Farbe	Clear colorless
Wasserlöslichkeit	Soluble in water.
BRN	1742952
LogP	0.870 (est)
CAS Datenbank	2935-90-2(CAS DataBase Reference)
NIST chemische Informationen	Propanoic acid, 3-mercapto-, methyl ester(2935-90-2)
EPA chemische Informationen	Propanoic acid, 3-mercapto-, methyl ester (2935-90-2)

Sicherheit

Kennzeichnung gefährlicher	T,Xi
R-Sätze:	22-23-36/37/38
S-Sätze:	45-37/39-26
RIDADR	UN 1993 3/PG 3
WGK Germany	3
RTECS-Nr.	UA2465980
F	13
TSCA	Yes
HazardClass	3
PackingGroup	II
HS Code	29309090
Giftige Stoffe Daten	2935-90-2(Hazardous Substances Data)

Gefahreninformationscode (GHS)

Methyl 3-mercaptopropionate Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
R23:Giftig beim Einatmen.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
Chemische Eigenschaften
CLEAR COLORLESS LIQUID
Verwenden
The Progress in Development of Dental Restorative Materials
Verwenden
Methyl 3-mercaptopropionate is a click chemistry reagent used in the modification of oxazolines using thiol-ene click modification. It also has implications for self-assembled monolayers (SAMs). It is used in the colorimetric detection of mercury(II) in a high-salinity solution using gold nanoparticles.
Verwenden
Methyl 3-Mercaptopropionate is used in the synthesis of thioisoindolinones.
Application
Methyl 3-mercaptopropionate is an important chemical raw material. It is an intermediate for preparing isothiazolinone and a raw material for preparing fine chemical 4-chloro-7-methylthiophene [3,2-D ] pyrimidine. The methyl 3-mercaptopropionate is a raw material for synthesizing a simvastatin side DMB-S-MMP3- [ (2, 2-dimethyl-1-oxobutyl) sulfur ] methyl propionate serving as a blood fat-reducing drug by an enzyme method. Simvastatin is listed in the essential drug list of the World Health Organization and belongs to one of the essential drugs of the basic medical system.
Flammability and Explosibility
Non flammable
Synthese
The traditional synthetic method of the Methyl 3-mercaptopropionate comprises the steps of adding 2% -5% of concentrated sulfuric acid as a catalyst in an inert atmosphere, refluxing (65-70 ℃) for a reaction for 15 hours, evaporating reaction liquid to remove methanol after the reaction is finished, and then deacidifying; during the deacidification process, a large amount of deionized water is added for water washing, and when the pH of the water washing solution is close to neutrality, the Methyl 3-mercaptopropionate product is obtained by reduced pressure distillation. Another method for preparing Methyl 3-mercaptopropionate is by using a reactive distillation technology. Mix the reactant 3-mercaptopropionic acid and methanol, then perform pre-reaction through a fixed bed reactor filled with a catalyst to obtain a crude product of the methyl 3-mercaptopropionate. The crude product is pumped to the middle part of the reaction rectifying tower by a feeding pump and is input; fresh methanol and a water-carrying agent are input from the lower part of the reaction rectifying tower, a catalyst is arranged at the lower part of the reaction rectifying tower, and unreacted 3-mercaptopropionic acid in the crude product continuously reacts with methanol in a catalyst bed layer of the reaction rectifying tower; after the reaction is finished, excess methanol, water carrying agent and water are extracted from the upper part of the reaction rectifying tower, and the product Methyl 3-mercaptopropionate is extracted from the bottom of the tower.

Methyl 3-mercaptopropionate Upstream-Materialien And Downstream Produkte

Methyl-3-mercaptopropionat Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

2935-90-2, Methyl 3-mercaptopropionate Verwandte Suche:

Send Inquriy