藏红花醛
- CAS号:116-26-7
- 英文名:SAFRANAL
- 中文名:藏红花醛
- CBNumber:CB9701548
- 分子式:C10H14O
- 分子量:150.22
- MOL File:116-26-7.mol
- 熔点 :<25 °C
- 沸点 :70 °C1 mm Hg(lit.)
- 密度 :0.966 g/mL at 25 °C(lit.)
- 蒸气压 :10.3Pa at 20℃
- 折射率 :n
20/D 1.523(lit.) - FEMA :3389 | 2,6,6-TRIMETHYLCYCLOHEXA-1,3-DIENYL METHANAL
- 闪点 :186 °F
- 储存条件 :Inert atmosphere,Store in freezer, under -20°C
- 溶解度 :Chloroform, Ethyl Acetate (Slightly), Methanol (Slightly)
- 形态 :Oil
- 颜色 :Yellow to Dark Yellow
- 气味 (Odor) :at 1.00 % in dipropylene glycol. fresh herbal phenolic metallic rosemary tobacco spicy
- 香型 :herbal
- 水溶解性 :514.9mg/L at 20℃
- Merck :13,8394
- JECFA Number :977
- BRN :1932918
- 稳定性 :Light Sensitive
- LogP :2.7 at 20℃
- EPA化学物质信息 :1,3-Cyclohexadiene-1-carboxaldehyde, 2,6,6-trimethyl- (116-26-7)
藏红花醛性质、用途与生产工艺
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简介
藏红花醛呈黄色液体状，溶于乙醇等有机溶剂。
- 用途 藏红花醛是藏红花中含有的一种化学成分，是一种批准为允许使用的食品香料，可用于调配老姆酒、无花果、茶叶以及木香香型、药草香型的食用香精。
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制备
藏红花醛可由藏红花中的苦味素一苦藏花素在酸中水解取得，或由β-环柠檬醛或a-环香叶酸用氧化硒催化脱氢制得。
- 生物活性 Safranal 是藏红花 (Crocus sativus) 的主要成分，具有口服活性，是这种香料的独特香气来源。Safranal 具有神经保护和抗炎作用，并有用于帕金森氏病的研究潜力。
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体外研究
Safranal (10-50 μM; for 1 h) dose-dependently decreases LPS-induced iNOS and COX-2 levels in both RAW264.7 cells and BMDMs.
Safranal (10-50 μM; for 1 h) inhibits cytokine IL-6 and TNF-α production and mRNA expression in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells.
Safranal (10, 50 μM; for 1 h followed by stimulation with 1 μg/ml of LPS for 30 min) inhibits the nuclear translocation of NF-κB and AP-1 in lipopolysaccharide (LPS)-stimulated RAW264.7 cells.
Western Blot Analysis
Cell Line: RAW264.7 cells and bone marrow-derived macrophages (BMDMs) Concentration: 10, 50 μM Incubation Time: For 1 h prior to lipopolysaccharide (LPS) stimulation (1 µg/ml) Result: Dose-dependently decreased LPS-induced iNOS and COX-2 levels in both RAW264.7 cells and BMDMs.
Inhibited the phosphorylation of MAPK pathway proteins extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), p38.
Inhibited NF-κB pathway proteins IKKα/β and IκBα and the degradation of IκBα.RT-PCR
Cell Line: RAW 264.7 cells Concentration: 10, 50 μM Incubation Time: For 1 h followed by stimulation with LPS (1 μg/ml) for 24 h Result: Inhibited cytokine IL-6 and TNF-α production and mRNA expression in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells. -
体内研究
Safranal (200-500 mg/kg; PO; for 7 days) causes a slight restoration of colon length and percentage of weight loss, and the DAI score is significantly low.
Animal Model: Female BALB/c mice (18-20 g) (DSS-induced colitis mice) Dosage: 200, 500 mg/kg Administration: PO; for 7 days Result: Caused a slight restoration of colon length and percentage of weight loss, and the DAI score is significantly low.
- 更新日期：2024/11/08
- 产品编号：HY-N7560
- 产品名称：藏红花醛 Safranal
- CAS编号：116-26-7
- 包装：500mg
- 价格：500元
- 公司名称：Aromor Israel
- 联系电话：--
- 电子邮件：itzikm@aromor.com
- 国家：以色列
- 产品数：25
- 优势度：51
