藏红花醛

简介用途制备生物活性体外研究体内研究藏红花醛试剂级价格

藏红花醛

CAS号:116-26-7
英文名:SAFRANAL
中文名:藏红花醛
CBNumber:CB9701548
分子式:C10H14O
分子量:150.22
MOL File:116-26-7.mol

藏红花醛化学性质

熔点 :<25 °C
沸点 :70 °C1 mm Hg(lit.)
密度 :0.966 g/mL at 25 °C(lit.)
蒸气压 :10.3Pa at 20℃
折射率 :n20/D 1.523(lit.)
FEMA :3389 | 2,6,6-TRIMETHYLCYCLOHEXA-1,3-DIENYL METHANAL
闪点 :186 °F
储存条件 :Inert atmosphere,Store in freezer, under -20°C
溶解度 :Chloroform, Ethyl Acetate (Slightly), Methanol (Slightly)
形态 :Oil
颜色 :Yellow to Dark Yellow
气味 (Odor) :at 1.00 % in dipropylene glycol. fresh herbal phenolic metallic rosemary tobacco spicy
香型 :herbal
水溶解性 :514.9mg/L at 20℃
JECFA Number :977
Merck :13,8394
BRN :1932918
稳定性 :Light Sensitive
LogP :2.7 at 20℃
EPA化学物质信息 :1,3-Cyclohexadiene-1-carboxaldehyde, 2,6,6-trimethyl- (116-26-7)

安全信息

危险品标志 :Xi
危险类别码 :36/37/38
安全说明 :26-36
WGK Germany :3

藏红花醛性质、用途与生产工艺

简介
藏红花醛呈黄色液体状，溶于乙醇等有机溶剂。
用途藏红花醛是藏红花中含有的一种化学成分，是一种批准为允许使用的食品香料，可用于调配老姆酒、无花果、茶叶以及木香香型、药草香型的食用香精。
制备
藏红花醛可由藏红花中的苦味素一苦藏花素在酸中水解取得，或由β-环柠檬醛或a-环香叶酸用氧化硒催化脱氢制得。
生物活性 Safranal 是藏红花 (Crocus sativus) 的主要成分，具有口服活性，是这种香料的独特香气来源。Safranal 具有神经保护和抗炎作用，并有用于帕金森氏病的研究潜力。

体外研究

Safranal (10-50 μM; for 1 h) dose-dependently decreases LPS-induced iNOS and COX-2 levels in both RAW264.7 cells and BMDMs.
Safranal (10-50 μM; for 1 h) inhibits cytokine IL-6 and TNF-α production and mRNA expression in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells.
Safranal (10, 50 μM; for 1 h followed by stimulation with 1 μg/ml of LPS for 30 min) inhibits the nuclear translocation of NF-κB and AP-1 in lipopolysaccharide (LPS)-stimulated RAW264.7 cells.

Western Blot Analysis

Cell Line:	RAW264.7 cells and bone marrow-derived macrophages (BMDMs)
Concentration:	10, 50 μM
Incubation Time:	For 1 h prior to lipopolysaccharide (LPS) stimulation (1 µg/ml)
Result:	Dose-dependently decreased LPS-induced iNOS and COX-2 levels in both RAW264.7 cells and BMDMs. Inhibited the phosphorylation of MAPK pathway proteins extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), p38. Inhibited NF-κB pathway proteins IKKα/β and IκBα and the degradation of IκBα.

RT-PCR

Cell Line:	RAW 264.7 cells
Concentration:	10, 50 μM
Incubation Time:	For 1 h followed by stimulation with LPS (1 μg/ml) for 24 h
Result:	Inhibited cytokine IL-6 and TNF-α production and mRNA expression in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells.

体内研究

Safranal (200-500 mg/kg; PO; for 7 days) causes a slight restoration of colon length and percentage of weight loss, and the DAI score is significantly low.

Animal Model:	Female BALB/c mice (18-20 g) (DSS-induced colitis mice)
Dosage:	200, 500 mg/kg
Administration:	PO; for 7 days
Result:	Caused a slight restoration of colon length and percentage of weight loss, and the DAI score is significantly low.