米诺地尔硫酸盐
- CAS号:83701-22-8
- 英文名:Minoxidil sulphate
- 中文名:米诺地尔硫酸盐
- CBNumber:CB9494019
- 分子式:C9H15N5O4S
- 分子量:289.31
- MOL File:83701-22-8.mol
- 熔点 :175-180°C
- 密度 :1.75±0.1 g/cm3(Predicted)
- RTECS号 :UV6260494
- 储存条件 :-20°C
- 溶解度 :Acetone (Slightly), DMSO (Slightly)
- 形态 :White solid.
- 酸度系数(pKa) :-4.99±0.18(Predicted)
- 颜色 :White to Off-White
- 稳定性 :Light Sensitive - Protect from Light, Store in Freezer
- InChI :InChI=1S/C9H15N5O4S/c10-7-6-8(13-4-2-1-3-5-13)12-9(11)14(7)18-19(15,16)17/h6,10H,1-5H2,(H2,11,12)(H,15,16,17)
- InChIKey :AGMYAAIWWVATKU-UHFFFAOYSA-N
- SMILES :C1(N)N(OS(O)(=O)=O)C(=N)C=C(N2CCCCC2)N=1
- CAS 数据库 :83701-22-8(CAS DataBase Reference)
- 危险品标志 :Xn,T+
- 危险类别码 :22-36/37/38-26/27/28
- 安全说明 :26-36-45-36/37/39-22
- WGK Germany :3
米诺地尔硫酸盐性质、用途与生产工艺
- 用途 米诺地尔硫酸盐为白色结晶性粉末，可用作降压药，生发剂医药中间体。
- 生物活性 Minoxidil sulfate 是一种有效的 ATP 敏感的 K+ 通道 (K+ channel) 激动剂，是米诺地尔的硫酸代谢物。Minoxidil sulfate 被认为是一种血管扩张试剂，在动物实验模型中，促进头发生长。
-
靶点
IC50: K channel
-
体外研究
Minoxidil sulfate (1-100 μM; 2 hours) significantly reduces the permeability of bloode-brain tumor barrier (BTB) in a monolayer of RBMEC in a time-dependent manner, additionally,the effects of MS on transendothelial electrical resistance (TEER) is Transendothelial electrical resistance (TEER) at 2 h with high concentration.Minoxidil sulfate (0-100 μM; 0-4 hours) increases the RhoA activation in brain tumor tissue by 1 h and the highest level appears at 2 h, it also significantly induces transient PKB phosphorylation at Ser-473, without affecting total PKB levels. Addiotionally, LY294002 partly prevents the phosphorylation of PKB induced by MS.
Western Blot Analysis
Cell Line: Rat brain microvascular endothelial cells (RBMECs) Concentration: 0-100 μM Incubation Time: 15 mins, 30 mins, 1 hour, 2 hours, 4 hours Result: Induced RhoA activation and PKB phosphorylation at Ser-473. -
用途
Minoxidil sulfate is the active metabolite of Minoxidil and is a potent (IC50=0.14μM) vascular smooth muscle relaxant. Minoxidil sulfate is a selective ATP-sensitive potassium channel opener.
- 更新日期：2024/11/11
- 产品编号：XW8370122802
- 产品名称：试剂Minoxidil sulphate Minoxidil sulphate
- CAS编号：
- 包装：25mg
- 价格：44元
- 更新日期：2024/11/08
- 产品编号：HY-B1445
- 产品名称：Minoxidil sulfate
- CAS编号：
- 包装：25 mg
- 价格：750元
- 公司名称：TORONTO
- 联系电话：--
- 电子邮件：info@trc-canada.com
- 国家：加拿大
- 产品数：6038
- 优势度：71
