双羟萘酸噻嘧啶

双羟萘酸噻嘧啶化学性质

熔点 :266-267°C
储存条件 :Sealed in dry,Room Temperature
溶解度 :Pratically insoluble in water, soluble in dimethyl sulfoxide, pratically insoluble in methanol.
形态 :powder
颜色 :yellow
水溶解性 :<0.1 g/100 mL at 19 ºC
BRN :9034755
BCS Class :4
InChIKey :AQXXZDYPVDOQEE-MXDQRGINSA-N
SMILES :C(C1=C(C(C(=O)O)=CC2=CC=CC=C12)O)C1=C(C(C(=O)O)=CC2=CC=CC=C12)O.C(/C1=NCCCN1C)=C\C1SC=CC=1
EPA化学物质信息 :2-Naphthalenecarboxylic acid, 4,4'-methylenebis[3-hydroxy-, compd. with 1,4,5,6-tetrahydro-1-methyl-2-[(1E)-2-(2-thienyl)ethenyl]pyrimidine (1:1) (22204-24-6)

安全信息

双羟萘酸噻嘧啶 MSDS

Pyrantel pamoate

生物活性 Pyrantel pamoate (Pyrantel Embonate)是一种广谱驱虫剂，用于治疗一些寄生虫感染。
体外研究

Pyrantel induces Ascaris suum muscle contraction, with a pEC ₅₀ of 7.24.
Pyrantel produces spastic paralysis of the nematode by selectively gating acetylcholine receptor ion-channels on nerve and muscle.
Pyrantel (72 h) inhibits the survival of Ancylostoma ceylanicum , Necator americanus and Trichuris muris on the third-stage larvae (IC ₅₀ s=90.9, 2.0, and 95.5 µg/mL, respectively) and adult worms (IC ₅₀ s=>100, 7.6, and 34.1 µg/mL, respectively).
体内研究

Pyrantel (10 mg/kg; a single p.o.) reduces the worms in A. ceylanicum -infected hamsters, with the worm burden reduction of 87.2% and worm expulsion rate of 63.4%.
化学性质黄色至褐色晶体粉末

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