生物活性 靶点 体外研究 体内研究 1-[5-ETHYL-2-HYDROXY-4-[[6-METHYL-6-(1H-TETRAZOL-5-YL)HEPTYL]OXY]PHENYL]ETHANONE 试剂级价格
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ChemicalBook  CAS数据库列表  1-[5-ETHYL-2-HYDROXY-4-[[6-METHYL-6-(1H-TETRAZOL-5-YL)HEPTYL]OXY]PHENYL]ETHANONE

1-[5-ETHYL-2-HYDROXY-4-[[6-METHYL-6-(1H-TETRAZOL-5-YL)HEPTYL]OXY]PHENYL]ETHANONE

生物活性 靶点 体外研究 体内研究 1-[5-ETHYL-2-HYDROXY-4-[[6-METHYL-6-(1H-TETRAZOL-5-YL)HEPTYL]OXY]PHENYL]ETHANONE 试剂级价格
1-[5-ETHYL-2-HYDROXY-4-[[6-METHYL-6-(1H-TETRAZOL-5-YL)HEPTYL]OXY]PHENYL]ETHANONE,117690-79-6,结构式
1-[5-ETHYL-2-HYDROXY-4-[[6-METHYL-6-(1H-TETRAZOL-5-YL)HEPTYL]OXY]PHENYL]ETHANONE
  • CAS号:117690-79-6
  • 英文名:1-[5-ETHYL-2-HYDROXY-4-[[6-METHYL-6-(1H-TETRAZOL-5-YL)HEPTYL]OXY]PHENYL]ETHANONE
  • 中文名:1-[5-ETHYL-2-HYDROXY-4-[[6-METHYL-6-(1H-TETRAZOL-5-YL)HEPTYL]OXY]PHENYL]ETHANONE
  • CBNumber:CB9257308
  • 分子式:C19H28N4O3
  • 分子量:360.45
  • MOL File:117690-79-6.mol
1-[5-ETHYL-2-HYDROXY-4-[[6-METHYL-6-(1H-TETRAZOL-5-YL)HEPTYL]OXY]PHENYL]ETHANONE化学性质
  • 熔点 :160-162 °C
  • 沸点 :573.4±60.0 °C(Predicted)
  • 密度 :1.157±0.06 g/cm3(Predicted)
  • 储存条件 :Store at +4°C
  • 溶解度 :DMSO: >20mg/mL
  • 形态 :powder
  • 酸度系数(pKa) :5.11±0.10(Predicted)
  • 颜色 :off-white to light yellow
安全信息
  • WGK Germany :2

1-[5-ETHYL-2-HYDROXY-4-[[6-METHYL-6-(1H-TETRAZOL-5-YL)HEPTYL]OXY]PHENYL]ETHANONE性质、用途与生产工艺

  • 生物活性 LY255283 是一种 leukotriene B4 (LTB4) receptor (BLT2) 的拮抗剂，可将 [3H]LTB4 从其在肺膜上的结合位点置换，pKi为7.0。
  • 靶点
    TargetValue
    BLT2
    (Cell-free assay)     		7.0(pKi)
  • 体外研究

    LY255283 competitively reduces conlractilc responses of lung parcnchyma to LTB, (pA 2 = 7.2).
    LY255283 (10 μM, 7 days) significantly suppresses the invasiveness of highly aggressive 253 J-BV bladder cancer cells.

    Cell Viability Assay

    Cell Line: 253 J-BV cells.
    Concentration: 5 or 10 μM.
    Incubation Time: 7 days.
    Result: Inhibition of BLT2 signaling attenuates aggressive migration by 253 J-BV cells.
  • 体内研究

    LY255283 (3, 30 mg/kg) ameliorates lipopolysaccharide-induced ARDS in pigs, possibly by blocking the recruitment of activated PMNs into alveoli in a dose-dependent fashion.
    LY255283 (2.5 mg/kg, ip) inhibits transitional cell carcinoma metastasis in mice models. The result suggests that a BLT2–Nox–ROS–NF–κB cascade plays a critical role in bladder cancer invasion and metastasis.

    Animal Model: Mice (253 J-BV cells injected).
    Dosage: 2.5 mg/kg.
    Administration: IP injected 3 and 5 days after injection of cells.
    Result: By 12 weeks after injection, in mice treated with LY255283 only 0-3 nodules formed per lung, and histological analysis confirmed that the number of micrometastatic lesions was markedly reduced.
1-[5-ETHYL-2-HYDROXY-4-[[6-METHYL-6-(1H-TETRAZOL-5-YL)HEPTYL]OXY]PHENYL]ETHANONE上下游产品信息
上游原料
下游产品
1-[5-ETHYL-2-HYDROXY-4-[[6-METHYL-6-(1H-TETRAZOL-5-YL)HEPTYL]OXY]PHENYL]ETHANONE 试剂级价格
  • 更新日期：2024/11/08
  • 产品编号：HY-15744
  • 产品名称：LY255283
  • CAS编号：
  • 包装：1 mg
  • 价格：550元
  • 更新日期：2024/11/08
  • 产品编号：HY-15744
  • 产品名称：1-[5-ETHYL-2-HYDROXY-4-[[6-METHYL-6-(1H-TETRAZOL-5-YL)HEPTYL]OXY]PHENYL]ETHANONE LY255283
  • CAS编号：117690-79-6
  • 包装：5mg
  • 价格：1200元
1-[5-ETHYL-2-HYDROXY-4-[[6-METHYL-6-(1H-TETRAZOL-5-YL)HEPTYL]OXY]PHENYL]ETHANONE生产厂家
  • 公司名称：TOCRIS-US
  • 联系电话：--
  • 电子邮件：customerservice@tocris.co.uk
  • 国家：英国
  • 产品数：5726
  • 优势度：77
  • 公司名称：Carbone Scientific CO., LTD
  • 联系电话：--
  • 电子邮件：sales@carbonesci.com
  • 国家：英国
  • 产品数：6666
  • 优势度：30
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