1-[5-ETHYL-2-HYDROXY-4-[[6-METHYL-6-(1H-TETRAZOL-5-YL)HEPTYL]OXY]PHENYL]ETHANONE
1-[5-ETHYL-2-HYDROXY-4-[[6-METHYL-6-(1H-TETRAZOL-5-YL)HEPTYL]OXY]PHENYL]ETHANONE
英文名称:1-[5-ETHYL-2-HYDROXY-4-[[6-METHYL-6-(1H-TETRAZOL-5-YL)HEPTYL]OXY]PHENYL]ETHANONE
CAS号:117690-79-6
分子式:C19H28N4O3
分子量:360.45
EINECS号:
Mol文件:117690-79-6.mol
![1-[5-ETHYL-2-HYDROXY-4-[[6-METHYL-6-(1H-TETRAZOL-5-YL)HEPTYL]OXY]PHENYL]ETHANONE 结构式](https://img.chemicalbook.com/CAS/GIF/117690-79-6.gif)
1-[5-ETHYL-2-HYDROXY-4-[[6-METHYL-6-(1H-TETRAZOL-5-YL)HEPTYL]OXY]PHENYL]ETHANONE 性质
| 熔点 | 160-162 °C |
|---|---|
| 沸点 | 573.4±60.0 °C(Predicted) |
| 密度 | 1.157±0.06 g/cm3(Predicted) |
| 储存条件 | Store at +4°C |
| 溶解度 | 二甲基亚砜：>20mg/mL |
| 形态 | 粉末 |
| 酸度系数(pKa) | 5.11±0.10(Predicted) |
| 颜色 | 灰白色至浅黄色 |
1-[5-ETHYL-2-HYDROXY-4-[[6-METHYL-6-(1H-TETRAZOL-5-YL)HEPTYL]OXY]PHENYL]ETHANONE 用途与合成方法
LY255283 是一种 leukotriene B4 (LTB4) receptor (BLT2) 的拮抗剂，可将 [3H]LTB4 从其在肺膜上的结合位点置换，pKi为7.0。
| Target | Value |
|
BLT2
(Cell-free assay) | 7.0(pKi) |
LY255283 competitively reduces conlractilc responses of lung parcnchyma to LTB, (pA
2
= 7.2).
LY255283 (10 μM, 7 days) significantly suppresses the invasiveness of highly aggressive 253 J-BV bladder cancer cells.
Cell Viability Assay
| Cell Line: | 253 J-BV cells. |
| Concentration: | 5 or 10 μM. |
| Incubation Time: | 7 days. |
| Result: | Inhibition of BLT2 signaling attenuates aggressive migration by 253 J-BV cells. |
LY255283 (3, 30 mg/kg) ameliorates lipopolysaccharide-induced ARDS in pigs, possibly by blocking the recruitment of activated PMNs into alveoli in a dose-dependent fashion.
LY255283 (2.5 mg/kg, ip) inhibits transitional cell carcinoma metastasis in mice models. The result suggests that a BLT2–Nox–ROS–NF–κB cascade plays a critical role in bladder cancer invasion and metastasis.
| Animal Model: | Mice (253 J-BV cells injected). |
| Dosage: | 2.5 mg/kg. |
| Administration: | IP injected 3 and 5 days after injection of cells. |
| Result: | By 12 weeks after injection, in mice treated with LY255283 only 0-3 nodules formed per lung, and histological analysis confirmed that the number of micrometastatic lesions was markedly reduced. |
1-[5-ETHYL-2-HYDROXY-4-[[6-METHYL-6-(1H-TETRAZOL-5-YL)HEPTYL]OXY]PHENYL]ETHANONE 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024-01-25 | HY-15744 | 1 mg | 636 | ||
| 2024-01-25 | HY-15744 | 1-[5-ETHYL-2-HYDROXY-4-[[6-METHYL-6-(1H-TETRAZOL-5-YL)HEPTYL]OXY]PHENYL]ETHANONE | 117690-79-6 | 5mg | 1400 |
1-[5-ETHYL-2-HYDROXY-4-[[6-METHYL-6-(1H-TETRAZOL-5-YL)HEPTYL]OXY]PHENYL]ETHANONE供应商 更多
武汉易泰科技有限公司上海分公司
联系电话：821-50328103-801 18930552037
产品介绍：
英文名称：LY 255283;1-[5-Ethyl-2-hydroxy-4-[[6-Methyl-6-(1H-tetrazol-5-yl)heptyl]oxy]phenyl]ethanone
CAS：117690-79-6
纯度：99% HPLC
包装信息：1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
广州爱纯医药科技有限公司
联系电话：020-39119399 18927568969
产品介绍：
英文名称：LY255283
CAS：117690-79-6
纯度：98.0%
包装信息：1G; 5G; 10G; 100G; 1KG
备注：品牌：StdSun | 提供定制合成服务（包括：小分子，药物杂质及医药中间体）
上海一飞生物科技有限公司
联系电话：021-65675885 18964387627
产品介绍：
英文名称：LY 255283
CAS：117690-79-6
纯度：98%
包装信息：1mg;5mg;10mg
备注：试剂级
上海瀚香生物科技有限公司
联系电话：17754423994 17754423994
产品介绍：
英文名称：LY255283
CAS：117690-79-6
纯度：98% HPLC LCMS
包装信息：100MG;1G
备注：量大优惠，现货促销
ChemeGen 中国
联系电话： 18818260767
产品介绍：
英文名称：LY255283
CAS：117690-79-6
纯度：98%
包装信息：10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
备注：品牌：ChemeGen
