ChemicalBook CAS数据库列表 1-[5-ETHYL-2-HYDROXY-4-[[6-METHYL-6-(1H-TETRAZOL-5-YL)HEPTYL]OXY]PHENYL]ETHANONE
1-[5-ETHYL-2-HYDROXY-4-[[6-METHYL-6-(1H-TETRAZOL-5-YL)HEPTYL]OXY]PHENYL]ETHANONE
生物活性 靶点 体外研究 体内研究
1-[5-ETHYL-2-HYDROXY-4-[[6-METHYL-6-(1H-TETRAZOL-5-YL)HEPTYL]OXY]PHENYL]ETHANONE 试剂级价格
![1-[5-ETHYL-2-HYDROXY-4-[[6-METHYL-6-(1H-TETRAZOL-5-YL)HEPTYL]OXY]PHENYL]ETHANONE,117690-79-6,结构式](https://www.chemicalbook.com/CAS/GIF/117690-79-6.gif)
- CAS号:117690-79-6
- 英文名:1-[5-ETHYL-2-HYDROXY-4-[[6-METHYL-6-(1H-TETRAZOL-5-YL)HEPTYL]OXY]PHENYL]ETHANONE
- 中文名:1-[5-ETHYL-2-HYDROXY-4-[[6-METHYL-6-(1H-TETRAZOL-5-YL)HEPTYL]OXY]PHENYL]ETHANONE
- CBNumber:CB9257308
- 分子式:C19H28N4O3
- 分子量:360.45
- MOL File:117690-79-6.mol
1-[5-ETHYL-2-HYDROXY-4-[[6-METHYL-6-(1H-TETRAZOL-5-YL)HEPTYL]OXY]PHENYL]ETHANONE化学性质
- 熔点 :160-162 °C
- 沸点 :573.4±60.0 °C(Predicted)
- 密度 :1.157±0.06 g/cm3(Predicted)
- 储存条件 :Store at +4°C
- 溶解度 :DMSO: >20mg/mL
- 形态 :powder
- 酸度系数(pKa) :5.11±0.10(Predicted)
- 颜色 :off-white to light yellow
安全信息
- WGK Germany :2
1-[5-ETHYL-2-HYDROXY-4-[[6-METHYL-6-(1H-TETRAZOL-5-YL)HEPTYL]OXY]PHENYL]ETHANONE性质、用途与生产工艺
- 生物活性 LY255283 是一种 leukotriene B4 (LTB4) receptor (BLT2) 的拮抗剂，可将 [3H]LTB4 从其在肺膜上的结合位点置换，pKi为7.0。
-
靶点
Target Value BLT2
(Cell-free assay)7.0(pKi) -
体外研究
LY255283 competitively reduces conlractilc responses of lung parcnchyma to LTB, (pA 2 = 7.2).
LY255283 (10 μM, 7 days) significantly suppresses the invasiveness of highly aggressive 253 J-BV bladder cancer cells.
Cell Viability Assay
Cell Line: 253 J-BV cells. Concentration: 5 or 10 μM. Incubation Time: 7 days. Result: Inhibition of BLT2 signaling attenuates aggressive migration by 253 J-BV cells. -
体内研究
LY255283 (3, 30 mg/kg) ameliorates lipopolysaccharide-induced ARDS in pigs, possibly by blocking the recruitment of activated PMNs into alveoli in a dose-dependent fashion.
LY255283 (2.5 mg/kg, ip) inhibits transitional cell carcinoma metastasis in mice models. The result suggests that a BLT2–Nox–ROS–NF–κB cascade plays a critical role in bladder cancer invasion and metastasis.
Animal Model: Mice (253 J-BV cells injected). Dosage: 2.5 mg/kg. Administration: IP injected 3 and 5 days after injection of cells. Result: By 12 weeks after injection, in mice treated with LY255283 only 0-3 nodules formed per lung, and histological analysis confirmed that the number of micrometastatic lesions was markedly reduced.
1-[5-ETHYL-2-HYDROXY-4-[[6-METHYL-6-(1H-TETRAZOL-5-YL)HEPTYL]OXY]PHENYL]ETHANONE上下游产品信息
上游原料
下游产品
1-[5-ETHYL-2-HYDROXY-4-[[6-METHYL-6-(1H-TETRAZOL-5-YL)HEPTYL]OXY]PHENYL]ETHANONE 试剂级价格
- 更新日期：2024/11/08
- 产品编号：HY-15744
- 产品名称：LY255283
- CAS编号：
- 包装：1 mg
- 价格：550元
- 更新日期：2024/11/08
- 产品编号：HY-15744
- 产品名称：1-[5-ETHYL-2-HYDROXY-4-[[6-METHYL-6-(1H-TETRAZOL-5-YL)HEPTYL]OXY]PHENYL]ETHANONE LY255283
- CAS编号：117690-79-6
- 包装：5mg
- 价格：1200元
1-[5-ETHYL-2-HYDROXY-4-[[6-METHYL-6-(1H-TETRAZOL-5-YL)HEPTYL]OXY]PHENYL]ETHANONE生产厂家
- 公司名称：Service Chemical Inc.
- 联系电话：--
- 电子邮件：sales@chemos-group.com
- 国家：德国
- 产品数：6350
- 优势度：71
- 公司名称：BIOTREND GmbH
- 联系电话：--
- 电子邮件：jaeger@biotrend.com
- 国家：德国
- 产品数：249
- 优势度：65
- 公司名称：BIOTREND Chemicals AG
- 联系电话：--
- 电子邮件：info@biotrend.ch
- 国家：德国
- 产品数：1250
- 优势度：62
117690-79-6, 1-[5-ETHYL-2-HYDROXY-4-[[6-METHYL-6-(1H-TETRAZOL-5-YL)HEPTYL]OXY]PHENYL]ETHANONE相关搜索:
