1-[2-(3,4-二甲氧基苯基)乙基]-4-(3-苯基丙基)哌嗪盐酸盐

CAS号:165377-44-6
英文名:SA-4503,1-(3,4-DIMETHOXYPHENETHYL)-4-(3-PHENYLPROPYL)PIPERAZINE DIHYDROCHLORIDE
中文名:1-[2-(3,4-二甲氧基苯基)乙基]-4-(3-苯基丙基)哌嗪盐酸盐
CBNumber:CB91011619
分子式:C23H32N2O2.2ClH
分子量:441.44
MOL File:165377-44-6.mol

1-[2-(3,4-二甲氧基苯基)乙基]-4-(3-苯基丙基)哌嗪盐酸盐化学性质

熔点 :250-252°C
储存条件 :2-8°C
溶解度 :Soluble in DMSO (up to 5 mg/ml) or in Water (up to at least 25 mg/ml)..
形态 :powder
颜色 :white to beige
水溶解性 :H2O: 2mg/mL, clear
稳定性 :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 1 month.

1-[2-(3,4-二甲氧基苯基)乙基]-4-(3-苯基丙基)哌嗪盐酸盐性质、用途与生产工艺

生物活性 Cutamesine dihydrochloride (SA4503 dihydrochloride; AGY94806 dihydrochloride) 是一种有效的 Sigma 1 受体激动剂，在豚鼠脑膜中的 IC50 值为 17.4 nM。
靶点

IC50: 17.4 nM (σ1receptor, guinea pig brain membranes)
体外研究

The sigma receptor might be involved in several diseases in the central nervous system. Cutamesine, a potent σ1receptor agonist, has 103-fold higher affinity for σ1 (IC ₅₀ =17.4 nM) than σ2 (IC ₅₀ =1,784 nM) sites in guinea pig brain membranes. Cutamesine is 14-fold selective for σ1 (K _i =4.6 nM) over σ2 (K _i =63.1 nM) sites in guinea pig brain homogenates. Cutamesine protects motor neuron NSC34 cells against superoxide dismutase 1 and serum free neurotoxicity. It upregulates the phosphorylation levels of Akt and extracellular signal-regulated kinase (ERK) 1/2. Cutamesine reduces the activation of the MAPK/ERK pathway and down-regulated the ionotropic glutamate receptor, GluR1.
体内研究

Cutamesine extends the survival time in the SOD1G93A mice.

1-[2-(3,4-二甲氧基苯基)乙基]-4-(3-苯基丙基)哌嗪盐酸盐上下游产品信息

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