1-[2-(3,4-二甲氧基苯基)乙基]-4-(3-苯基丙基)哌嗪盐酸盐
1-[2-(3,4-二甲氧基苯基)乙基]-4-(3-苯基丙基)哌嗪盐酸盐
![1-[2-(3,4-二甲氧基苯基)乙基]-4-(3-苯基丙基)哌嗪盐酸盐 结构式](https://img.chemicalbook.com/CAS/GIF/165377-44-6.gif)
1-[2-(3,4-二甲氧基苯基)乙基]-4-(3-苯基丙基)哌嗪盐酸盐 性质
| 熔点 | 250-252°C |
|---|---|
| 储存条件 | 2-8°C |
| 溶解度 | 溶于DMSO（高达5mg/ml）或水（高达至少25mg/ml）。 |
| 形态 | 粉末 |
| 颜色 | 白色至米色 |
| 水溶解性 | H2O: 2mg/mL, clear |
| 稳定性 | 自购买之日起 1 年内保持稳定。 DMSO 或蒸馏水中的溶液可在 -20° 下储存长达 1 个月。 |
| InChI | 1S/C23H32N2O2.2ClH/c1-26-22-11-10-21(19-23(22)27-2)12-14-25-17-15-24(16-18-25)13-6-9-20-7-4-3-5-8-20;;/h3-5,7-8,10-11,19H,6,9,12-18H2,1-2H3;2*1H |
| InChIKey | XWOXAKBQEMQMFH-UHFFFAOYSA-N |
| SMILES | COC1=CC=C(CCN2CCN(CCCC3=CC=CC=C3)CC2)C=C1OC |
1-[2-(3,4-二甲氧基苯基)乙基]-4-(3-苯基丙基)哌嗪盐酸盐 用途与合成方法
IC50: 17.4 nM (σ1receptor, guinea pig brain membranes)
The sigma receptor might be involved in several diseases in the central nervous system. Cutamesine, a potent σ1receptor agonist, has 103-fold higher affinity for σ1 (IC 50 =17.4 nM) than σ2 (IC 50 =1,784 nM) sites in guinea pig brain membranes. Cutamesine is 14-fold selective for σ1 (K i =4.6 nM) over σ2 (K i =63.1 nM) sites in guinea pig brain homogenates. Cutamesine protects motor neuron NSC34 cells against superoxide dismutase 1 and serum free neurotoxicity. It upregulates the phosphorylation levels of Akt and extracellular signal-regulated kinase (ERK) 1/2. Cutamesine reduces the activation of the MAPK/ERK pathway and down-regulated the ionotropic glutamate receptor, GluR1.
Cutamesine extends the survival time in the SOD1G93A mice.
1-[2-(3,4-二甲氧基苯基)乙基]-4-(3-苯基丙基)哌嗪盐酸盐 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026-06-05 | HY-13510R | 1-[2-(3,4-二甲氧基苯基)乙基]-4-(3-苯基丙基)哌嗪盐酸盐 | 165377-44-6 | 5 mg | 1500 |
| 2026-06-05 | HY-13510R | 1-[2-(3,4-二甲氧基苯基)乙基]-4-(3-苯基丙基)哌嗪盐酸盐 | 165377-44-6 | 10 mg | 2400 |
