一水没食子酸

性质作用生物活性靶点体外研究体内研究一水没食子酸试剂级价格

一水没食子酸

CAS号:5995-86-8
英文名:Gallic acid monohydrate
中文名:一水没食子酸
CBNumber:CB8853938
分子式:C7H8O6
分子量:188.13
MOL File:5995-86-8.mol

一水没食子酸化学性质

熔点 :252 °C (dec.)(lit.)
密度 :1.694
闪点 :250 °C
储存条件 :Keep in dark place,Sealed in dry,Room Temperature
溶解度 :It is soluble in alcohol, ether, glycerol, acetone negligible in benzene, chloroform, petroleum ether.
形态 :Solid
颜色 :White to cream
水溶解性 :15 g/l (20 ºC)
敏感性 :Hygroscopic
Merck :14,4345
BRN :2050274
稳定性 :Light Sensitive
InChI :InChI=1S/C7H6O5.H2O/c8-4-1-3(7(11)12)2-5(9)6(4)10;/h1-2,8-10H,(H,11,12);1H2
InChIKey :IUTKPPDDLYYMBE-UHFFFAOYSA-N
SMILES :C(O)(=O)C1=CC(O)=C(O)C(O)=C1.[H]O[H]
CAS 数据库 :5995-86-8(CAS DataBase Reference)

安全信息

危险品标志 :Xi
危险类别码 :36/37/38
安全说明 :26-36-24/25
WGK Germany :2
RTECS号 :LW7525000
F :8-9-23
TSCA :Yes
海关编码 :29182900

一水没食子酸化学药品说明书

六味地黄丸—没食子酸的测定—毛细管区带电泳法|药物分析方法信息
六味地黄丸—没食子酸/泽泻醇A乙酸酯/番木鳖苷/莫罗苷/羟基芍药苷/梓醇/苯甲酰羟基芍药苷/泽泻醇B/熊果酸—高效液相色谱/电喷雾电离—质谱分析|药物分析方法信息

一水没食子酸性质、用途与生产工艺

性质一水没食子酸在常温常压下为白色至米白色固体状，其具有较强的酸性。
作用
一水没食子酸是一种天然多羟基酚类化合物，具有抑制环氧合酶-2 (COX-2) 的自由基清除作用；在制药、食品、轻工诸方面均有广泛用途，也用作分析试剂，还用于制造墨水及照相业。
生物活性 Gallic acid (3,4,5-Trihydroxybenzoic acid) hydrate 是一种天然多羟基酚类化合物，具有抑制环氧合酶-2 (COX-2) 的自由基清除作用。Gallic acid hydrate 具有多种活性，如抗菌、抗氧化、抗菌、抗炎和抗肿瘤活性。
靶点

COX-2

Human Endogenous Metabolite
体外研究

Gallic acid is an antioxidant which can inhibit both COX-2. After 18 h treatment with Gallic acid, the number of viable neutrophils is dramatically decreased from 40.3% to 27.7%, highly comparable with 26.4% for untreated neutrophils. Gallic acid fails to attenuate isoproterenol-induced myocytolysis.
体内研究

The food intake (2.6±0.08 g/day, p=0.69) and the body weight (2.5±0.69 g, p=0.76) of the Gallic acid group do not differ significantly from those of the control group (food intake; 2.41±0.14 g/day and the body weight; 2.83±0.84 g/day). The blood glucose tolerance in the Gallic acid group is significantly improved after 2 weeks of treatment. The blood glucose tolerance of the Gallic acid group after a treatment period of 2 weeks is also significantly better than that of the control group at 90 and 120 min ( p<0.05). The serum triglyceride concentration in the Gallic acid group (0.67±0.03 mM, p<0.05) is significantly reduced relative to that of the control group (1.08±0.20 mM). The total cholesterol concentration is similar in the control (3.19±0.27 mM) and Gallic acid (3.01±0.18 mM) groups.
化学性质白色或淡黄色针状晶体，或棱柱状晶体。有绢丝光泽，味微酸。溶于乙醇、丙酮、乙二醇，微溶于水、乙醚。
用途用于制造噻嗪染料、恶嗪染料、药物等
用途用作电化分析中的去极剂；用于还原磷钼酸；用于检定锑、钡、铋、钙、铈和铜等；用于测定磷、亚硝酸盐、银、钍和钛等
用途试验游离矿酸、二羟基丙酮和生物碱等，电化分析中的去极剂，还原磷钼酸，检定锑、钡、铋、钙、铈和铜等。测定磷、亚硝酸盐、银、钍和钛等。
类别有毒物质
毒性分级中毒
急性毒性静脉-小鼠 LD50: 320 毫克/公斤
可燃性危险特性可燃, 火场排出辛辣刺激烟雾
储运特性库房低温, 通风, 干燥
灭火剂水, 二氧化碳, 干粉, 砂土