ALPHA-玉米赤霉烯醇
- CAS号:36455-72-8
- 英文名:ALPHA-ZEARALENOL
- 中文名:ALPHA-玉米赤霉烯醇
- CBNumber:CB8491950
- 分子式:C18H24O5
- 分子量:320.38
- MOL File:36455-72-8.mol
- 熔点 :158-161°C
- 沸点 :599.0±50.0 °C(Predicted)
- 密度 :1.174±0.06 g/cm3(Predicted)
- 闪点 :2℃
- 储存条件 :-20°C
- 溶解度 :≤20mg/ml in ethanol;30mg/ml in DMSO;30mg/ml in dimethyl formamide
- 形态 :crystalline solid
- 酸度系数(pKa) :7.61±0.60(Predicted)
- 颜色 :White to off-white
- 稳定性 :Hygroscopic
- 危险品标志 :Xn,T,F
- 危险类别码 :20/21/22-40-52/53-68/20/21/22-36-11-62-48/20-63-46-45
- 安全说明 :36/37-61-16-45-53
- 危险品运输编号 :UN 1648 3 / PGII
- WGK Germany :3
- F :8
- 海关编码 :29322090
ALPHA-玉米赤霉烯醇性质、用途与生产工艺
- 生物活性 α-Zearalenol 是一种对雌激素受体 (ER) 具有高亲和力的霉菌毒素, α-Zearalenol 是 zearalenone (ZEN) 的衍生物，由于其异种雌激素效应可引起动物的生殖障碍。
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体外研究
α-Zearalenol (α-zol) (0.001-10 μM; 24-72 hours) shows the highest RPE (90.5%) at 9.37 µM α-ZOL exposure in MFC-7 cells with an IC 50 of 12.5 μM. α-Zearalenol (α-zol) (0.001-10 μM; 24-72 hours) induces an increase of cell viability on MCF-7 cells mainly after 72 h of treatment whereas it is slightly cytotoxic on MDA-MB231 cells. α-Zearalenol (α-zol) (0.001-10 μM; 24-72 hours) increases MCF7 cell population in the S phase and in the G2/M phase, no visible change in cell cycle phases is observed in MDA-MB231 cells. α-Zearalenol (α-zol) (1-10 μM; 24 hours) reduces the expression of TNF-α, α-ZOL combines with β-ZOL shows an antagonistic effect on inflammation for IL-1β and act synergic for IL-8 at high toxin concentrations.
Cell Proliferation Assay
Cell Line: MFC-7 cells Concentration: 6.25 µM-25 µM Incubation Time: 24 hours Result: Observed the highest RPE (90.5%) at 9.37 µM α-ZOL exposure in MFC-7 cells. Cell Viability Assay
Cell Line: Breast cancer cell lines: MCF-7 and MDA-MB231 Concentration: 0.001 μM, 0.1 μM and 10 μM Incubation Time: 24 hours, 48 hours, 72 hours Result: Modified the cell growth in two breast cancer cell lines. Cell Cycle Analysis
Cell Line: MCF7 cells, MDA-MB231 cells Concentration: 0.001 μM, 0.1 μM and 10 μM Incubation Time: 72 hours Result: Observed an increase of cells in cell cycle in MCF7 cells. RT-PCR
Cell Line: HepG2 cells Concentration: 1 μM, 5 μM, 10 μM Incubation Time: 72 hours Result: Induced a decrease of the expression of TNF-α, IL-1β and IL-8, that was in most cases statistically significant for the higher doses.
- 更新日期：2024/11/08
- 产品编号：HY-N6710
- 产品名称：α-Zearalenol
- CAS编号：
- 包装：1 mg
- 价格：1066元
- 更新日期：2024/11/08
- 产品编号：HY-N6710
- 产品名称：ALPHA-玉米赤霉烯醇 α-Zearalenol
- CAS编号：36455-72-8
- 包装：5mg
- 价格：2800元
- 公司名称：CHIRON
- 联系电话：--
- 电子邮件：chiron@chiron.no
- 国家：挪威
- 产品数：2801
- 优势度：72
