ALPHA-玉米赤霉烯醇
ALPHA-玉米赤霉烯醇 性质
| 熔点 | 158-161°C |
|---|---|
| 沸点 | 599.0±50.0 °C(Predicted) |
| 密度 | 1.174±0.06 g/cm3(Predicted) |
| 闪点 | 2℃ |
| 储存条件 | -20°C |
| 溶解度 | 乙醇中≤20mg/ml；DMSO 中≤30mg/ml；二甲基甲酰胺中≤30mg/ml |
| 形态 | 结晶固体 |
| 酸度系数(pKa) | 7.61±0.60(Predicted) |
| 颜色 | 白色至米白色 |
| 稳定性 | 吸湿性 |
| 主要应用 | 清洁产品 化妆品 食品和饮料 个人护理 |
| InChI | InChI=1S/C18H24O5/c1-12-6-5-9-14(19)8-4-2-3-7-13-10-15(20)11-16(21)17(13)18(22)23-12/h3,7,10-12,14,19-21H,2,4-6,8-9H2,1H3/b7-3+/t12-,14+/m0/s1 |
| InChIKey | FPQFYIAXQDXNOR-QDKLYSGJSA-N |
| SMILES | O1C(=O)C2=C(O)C=C(O)C=C2C=CCCC[C@@H](O)CCC[C@@H]1C |t:12| |
ALPHA-玉米赤霉烯醇 用途与合成方法
α-Zearalenol (α-zol) (0.001-10 μM; 24-72 hours) shows the highest RPE (90.5%) at 9.37 µM α-ZOL exposure in MFC-7 cells with an IC 50 of 12.5 μM. α-Zearalenol (α-zol) (0.001-10 μM; 24-72 hours) induces an increase of cell viability on MCF-7 cells mainly after 72 h of treatment whereas it is slightly cytotoxic on MDA-MB231 cells. α-Zearalenol (α-zol) (0.001-10 μM; 24-72 hours) increases MCF7 cell population in the S phase and in the G2/M phase, no visible change in cell cycle phases is observed in MDA-MB231 cells. α-Zearalenol (α-zol) (1-10 μM; 24 hours) reduces the expression of TNF-α, α-ZOL combines with β-ZOL shows an antagonistic effect on inflammation for IL-1β and act synergic for IL-8 at high toxin concentrations.
Cell Proliferation Assay
| Cell Line: | MFC-7 cells |
| Concentration: | 6.25 µM-25 µM |
| Incubation Time: | 24 hours |
| Result: | Observed the highest RPE (90.5%) at 9.37 µM α-ZOL exposure in MFC-7 cells. |
Cell Viability Assay
| Cell Line: | Breast cancer cell lines: MCF-7 and MDA-MB231 |
| Concentration: | 0.001 μM, 0.1 μM and 10 μM |
| Incubation Time: | 24 hours, 48 hours, 72 hours |
| Result: | Modified the cell growth in two breast cancer cell lines. |
Cell Cycle Analysis
| Cell Line: | MCF7 cells, MDA-MB231 cells |
| Concentration: | 0.001 μM, 0.1 μM and 10 μM |
| Incubation Time: | 72 hours |
| Result: | Observed an increase of cells in cell cycle in MCF7 cells. |
RT-PCR
| Cell Line: | HepG2 cells |
| Concentration: | 1 μM, 5 μM, 10 μM |
| Incubation Time: | 72 hours |
| Result: | Induced a decrease of the expression of TNF-α, IL-1β and IL-8, that was in most cases statistically significant for the higher doses. |
安全信息
| 危险品标志 | Xn,T,F |
|---|---|
| 危险类别码 | 20/21/22-40-52/53-68/20/21/22-36-11-62-48/20-63-46-45 |
| 安全说明 | 36/37-61-16-45-53 |
| 危险品运输编号 | UN 1648 3 / PGII |
| WGK Germany | 3 |
| F | 8 |
| 海关编码 | 29322090 |
| 存储类别 | 3- 易燃液体 |
| 危险性类别 | 急性毒性 类别4 经皮 急性毒性 类别4 吸入 急性毒性 类别4 经口 眼部刺激 类别2 易燃液体 类别2 |
ALPHA-玉米赤霉烯醇 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026-09-15 | HY-N6710 | ALPHA-玉米赤霉烯醇 | 36455-72-8 | 1 mg | 1066 |
| 2026-09-15 | HY-N6710 | ALPHA-玉米赤霉烯醇 | 36455-72-8 | 5mg | 2800 |
