芹甙元-7-葡萄糖苷

芹甙元-7-葡萄糖苷化学性质

熔点 :230-237°C
沸点 :788.9±60.0 °C(Predicted)
密度 :1.642±0.06 g/cm3(Predicted)
储存条件 :Inert atmosphere,2-8°C
溶解度 :DMSO (Slightly, Sonicated), Methanol (Slightly)
酸度系数(pKa) :6.13±0.40(Predicted)
形态 :Solid
颜色 :Pale Yellow to Yellow
BRN :65669
稳定性 :Hygroscopic
InChIKey :KMOUJOKENFFTPU-YUVSVTSJNA-N
SMILES :C1(C2=CC=C(O)C=C2)OC2=C(C(=CC(OC3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)=C2)O)C(=O)C=1 |&1:17,20,22,24,r|
LogP :-0.040 (est)
CAS 数据库 :578-74-5(CAS DataBase Reference)

安全信息

芹甙元-7-葡萄糖苷性质、用途与生产工艺

生物活性 Apigenin-7-glucoside (Apigenin-7-O-β-D-glucopyranoside)，ROS 清除剂，具有抗增殖，抗氧化活性。
体外研究

Apigenin 7-glucoside exhibits significant anti-proliferative activity against B16F10 melanoma cells after 24 and 48 h of incubation. Apigenin-7-glucoside provoks an increase of subG0/G1, S and G2/M phase cell proportion with a significant decrease of cell proportion in G0/G1 phases. Apigenin-7-glucoside enhances melanogenesis synthesis and tyrosinase activity of B16F10 melanoma cells.
Apigenin 7-glucoside specifically induces the differentiation of CD34 ⁺ cells towards the erythroid lineage and inhibited the myeloid differentiation. Apigenin 7-glucoside has strong antioxidant activity against reactive oxygen species (ROS) in vitro in a concentration-dependent manner.
化学性质白色结晶体，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于广藿香、仙鹤草，蓰草，构树叶。
用途用于含量测定/鉴定/药理实验等。
药理药效:抗肿瘤、消炎、抗病毒。

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