莪术呋喃烯
- CAS号:17910-09-7
- 英文名:Curzerene
- 中文名:莪术呋喃烯
- CBNumber:CB81469927
- 分子式:C15H20O
- 分子量:216.32
- MOL File:17910-09-7.mol
- 沸点 :282.8±40.0℃ (760 Torr)
- 密度 :0.982±0.06 g/cm3 (20 ºC 760 Torr)
- 闪点 :117.5±14.2℃
- 溶解度 :Soluble in chloroform
- 形态 :liquid
- 颜色 :Yellow oily
- LogP :3.982 (est)
莪术呋喃烯性质、用途与生产工艺
- 概述 莪术呋喃烯是一种有机杂环化合物，具有抗肿瘤作用，可以制备药物组合物。
- 生物活性 Curzerene 是倍半萜，从 Curculigo orchioides Gaertn 的根茎中分离出来的，具有抗癌活性。 Curzerene 抑制谷胱甘肽 S-转移酶 A1 (GSTA1) mRNA 和蛋白表达。Curzerene 诱导细胞凋亡 (apoptosis)。
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靶点
GSTA1
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体外研究
Curzerene (0-100 µM; 24-72 hours) indicates that cell inhibition increases in a dose- and time-dependent manner, IC 50 to SPC A1 cells at 24, 48, and 72 h was 403.8 μM, 154.8 µM, and 47.01 µM, respectively. Curzerene (0-100 µM; 48 hours) exhibits a higher percentage of apoptotic and necrotic cells than that of the control group in SPC-A1cells. Curzerene(0-100 µM; 48 hours) indicates that the percentage of cells arrested in the G2/M phase increased from 9.26% in the control group cells to 17.57% in the cells treated with the highest dose. Curzerene (6.25-100 µM; 48 hours) decreases the mRNA expression of GSTA1 in SPC A1 cells. Curzerene (6.25-100 µM; 48 hours) decreases the protein expression of GSTA1 in SPC A1 cells.
Cell Viability Assay
Cell Line: SPC-A1 cells Concentration: 0 µM, 6.25 µM, 12.5 µM, 25 µM, 50 µM, 100 µM Incubation Time: 24 hours, 48 hours, 72 hours Result: Inhibited growth of non-small cell lung cancer SPC A1 cells in vitro. Apoptosis Analysis
Cell Line: SPC-A1 cells Concentration: 0 µM, 6.25 µM, 12.5 µM, 25 µM, 50 µM, 100 µM Incubation Time: 48 hours Result: Induced apoptosis of the cells in a dose-dependent manner. Apoptosis Analysis
Cell Line: SPC-A1 cells Concentration: 0 µM, 6.25 µM, 12.5 µM, 25 µM, 50 µM, 100 µM Incubation Time: 48 hours Result: Induced G2/M cell cycle arrest of SPC A1 cells. RT-PCR
Cell Line: SPC-A1 cells Concentration: 6.25 µM, 25 µM, 100 µM Incubation Time: 48 hours Result: Decreased GSTA1 mRNA expression. - 化学性质 无色晶体，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于莪术。
- 用途 莪术烯具有行气破血，消积止痛。用于燀瘕痞块，瘀血经闭，食积胀痛；早期宫颈癌的作用。
- 更新日期：2024/11/08
- 产品编号：HY-N1963
- 产品名称：莪术呋喃烯 Curzerene
- CAS编号：17910-09-7
- 包装：1mg
- 价格：500元
- 更新日期：2024/11/08
- 产品编号：HY-N1963
- 产品名称：Curzerene
- CAS编号：
- 包装：1 mg * 5
- 价格：1600元
- 公司名称：Carbosynth
- 联系电话：--
- 电子邮件：sales@carbosynth.com
- 国家：英国
- 产品数：6005
- 优势度：58
