莪术呋喃烯

概述生物活性靶点体外研究莪术呋喃烯试剂级价格

莪术呋喃烯

CAS号:17910-09-7
英文名:Curzerene
中文名:莪术呋喃烯
CBNumber:CB81469927
分子式:C15H20O
分子量:216.32
MOL File:17910-09-7.mol

莪术呋喃烯化学性质

沸点 :282.8±40.0℃ (760 Torr)
密度 :0.982±0.06 g/cm3 (20 ºC 760 Torr)
闪点 :117.5±14.2℃
溶解度 :Soluble in chloroform
形态 :liquid
颜色 :Yellow oily
LogP :3.982 (est)

莪术呋喃烯性质、用途与生产工艺

概述莪术呋喃烯是一种有机杂环化合物，具有抗肿瘤作用，可以制备药物组合物。
生物活性 Curzerene 是倍半萜，从 Curculigo orchioides Gaertn 的根茎中分离出来的，具有抗癌活性。 Curzerene 抑制谷胱甘肽 S-转移酶 A1 (GSTA1) mRNA 和蛋白表达。Curzerene 诱导细胞凋亡 (apoptosis)。
靶点

GSTA1

体外研究

Curzerene (0-100 µM; 24-72 hours) indicates that cell inhibition increases in a dose- and time-dependent manner, IC ₅₀ to SPC A1 cells at 24, 48, and 72 h was 403.8 μM, 154.8 µM, and 47.01 µM, respectively. Curzerene (0-100 µM; 48 hours) exhibits a higher percentage of apoptotic and necrotic cells than that of the control group in SPC-A1cells. Curzerene(0-100 µM; 48 hours) indicates that the percentage of cells arrested in the G2/M phase increased from 9.26% in the control group cells to 17.57% in the cells treated with the highest dose. Curzerene (6.25-100 µM; 48 hours) decreases the mRNA expression of GSTA1 in SPC A1 cells. Curzerene (6.25-100 µM; 48 hours) decreases the protein expression of GSTA1 in SPC A1 cells.

Cell Viability Assay

Cell Line:	SPC-A1 cells
Concentration:	0 µM, 6.25 µM, 12.5 µM, 25 µM, 50 µM, 100 µM
Incubation Time:	24 hours, 48 hours, 72 hours
Result:	Inhibited growth of non-small cell lung cancer SPC A1 cells in vitro.

Apoptosis Analysis

Cell Line:	SPC-A1 cells
Concentration:	0 µM, 6.25 µM, 12.5 µM, 25 µM, 50 µM, 100 µM
Incubation Time:	48 hours
Result:	Induced apoptosis of the cells in a dose-dependent manner.

Apoptosis Analysis

Cell Line:	SPC-A1 cells
Concentration:	0 µM, 6.25 µM, 12.5 µM, 25 µM, 50 µM, 100 µM
Incubation Time:	48 hours
Result:	Induced G2/M cell cycle arrest of SPC A1 cells.