2-[[(2-羟基-1-萘基)亚甲基]氨基]-N-(1-苯基乙基)苯甲酰胺

2-[[(2-羟基-1-萘基)亚甲基]氨基]-N-(1-苯基乙基)苯甲酰胺化学性质

熔点 :119-120℃
沸点 :659.2±50.0 °C(Predicted)
密度 :1.16
储存条件 :-20°C
溶解度 :Soluble in DMSO (up to 30 mg/ml).
形态 :Yellow solid
酸度系数(pKa) :7.85±0.50(Predicted)
颜色 :Pale yellow
水溶解性 :Soluble in water, DMSO and methanol
稳定性 :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.

安全信息

2-[[(2-羟基-1-萘基)亚甲基]氨基]-N-(1-苯基乙基)苯甲酰胺性质、用途与生产工艺

生物活性 Sirtinol 是 sirtuin (SIRT) 的抑制剂，对 ySir2，hSIRT2 和 hSIRT2 的 IC50 值分别为 48 μM，57.7 μM 和 131 μM。

靶点

ySir2

48 μM (IC ₅₀ )

hSIRT2

57.7 μM (IC ₅₀ )

hSIRT1

131 μM (IC ₅₀ )

体外研究

Sirtinol reduces the growth of MCF-7 cells in a concentration- and time-dependent manner. The IC ₅₀ values of sirtinol are 48.6 μM and 43.5 μM after 24 and 48 h of treatment, respectively. Sirtinol significantly decreases SIRT1 expression and increases the acetylated p53 level. Sirtinol attenuates the proliferation and induces apoptosis of nonsmall cell lung cancer (NSCLC) H1299 cells and causes the significantly increased level of FoxO3a, a proapoptotic transcription factor targeted by Sirt1.
体内研究

Sirtinol has anti-inflammatory effects through direct inhibition of HNE activity and attenuates HNE-induced and LPS-mediated tissue or organ injury.

2-[[(2-羟基-1-萘基)亚甲基]氨基]-N-(1-苯基乙基)苯甲酰胺上下游产品信息

上游原料

下游产品

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