倍氯米松

倍氯米松化学性质

熔点 :217- 222°C (dec.)
沸点 :600.2±55.0 °C(Predicted)
密度 :1.35±0.1 g/cm3(Predicted)
储存条件 :2-8°C
溶解度 :Dioxane (Sparingly, Sonicated), DMSO (Sparingly), Ethyl Acetate (Slightly), Methane
形态 :Solid
酸度系数(pKa) :12.17±0.70(Predicted)
颜色 :White to Pale Beige
Merck :13,1020
稳定性 :Hygroscopic
CAS 数据库 :4419-39-0(CAS DataBase Reference)

安全信息

倍氯米松化学药品说明书

倍氯米松|药物应用信息

适应症用于治疗湿疹、过敏性皮炎、神经性皮炎、扁平苔藓、盘状红斑狼疮、掌跖脓疱病、接触性皮炎、局限性银屑病、皮肤瘙痒症等。丙酸倍氯米松气雾剂用于慢性或过敏性哮喘及过敏性鼻炎等。
生物活性 Beclometasone (Beclomethasone) 是一种糖皮质激素受体 (glucocorticoid receptor) 激动剂。
靶点

Glucocorticoid Receptor
体外研究

An inhibition of the normal physiological neutrophil migration and of neutrophil chemotaxis directed by wounding-induced inflammation is detected at 4 h after administration of 25 μM Beclomethasone. Tumour cell invasion and micrometastasis is also reduced in embryos incubated in 25 μM Beclomethasone 4 h before implantation. In addition, the lysyl oxidase inhibitor β-aminoproprionitrile (βAPN) largely reduces fibrillar collagen and enhances the CHT-TF transmigration of neutrophils, leading to a significant increase of tumour cell invasion and subsequent formation of micrometastases. Notably, βAPN inhibits neutrophil chemotaxis induced by inflammation, indicating that the increase of tumour cell invasion in βAPN-treated embryos is correlated with enhanced non-pathological neutrophil migration, but not with inflammation.
化学性质结晶化合物，熔点为198℃。
用途制取倍氯米松二丙酸酯。
生产方法由地塞米松制得。