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4419-39-0

供应商 相关产品 基本信息 物理化学性质 应用领域 安全数据 制备方法 上下游产品信息 常见问题列表 知名试剂公司产品信息

产品图片

基本信息

中文
倍氯米松
英文名称
1,4-PREGNADIEN-9-ALPHA-CHLORO-16-BETA-METHYL-11-BETA, 17-ALPHA, 21-TRIOL-3,20-DIONE
9ALPHA-CHLORO-16BETA-METHYL-1,4-PREGNADIENE-11BETA,17ALPHA,21-TRIOL-3,20-DIONE
BECLOMETHASONE
9alpha-Chloro-16beta-methylprednisolone
9-Chloro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione
9-Chloro-11beta,17,21-trihydroxy-16beta-methyl-pregna-1,4-diene-3,20-dione
Beclometasone
Pregna-1,4-diene-3,20-dione, 9-chloro-11,17,21-trihydroxy-16-methyl-, (11beta,16beta)-
BeclomethasoneDipropionateBase
Beclomethasone Dipropionate 5534-09-8 /Base
9-Chloro-16-methylpregna-1,4-diene-11,17,21-triol-3,20-dione
Beclomethasone (base and/or unspecified salts)
(9-α-Chloro-16-beta-methylprednisolone)
(11,16)-9-Chloro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione
9a-Chloro-16-methylprednisolone
Becolvent
9α-Chloro-16β-methyl-1,4-pregnadiene-11β,17α,21-triol-3,20-dione, 9α-Chloro-11β,17α,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione
CAS
4419-39-0
中文名称
9α-氯-11β,17α,21-三羟基-16β-甲基孕甾-1,4-二烯-3,20-二酮
9α-氯-16β-甲基孕甾-1,4-二烯-11β,17α,21-三醇-3,20-二酮
倍氯米松
倍氯美松
EINECS 编号
224-585-9
分子式
C22H29ClO5
MDL 编号
MFCD00135614
分子量
408.92
MOL 文件
4419-39-0.mol

物理化学性质

熔点 
217- 222°C (dec.)
储存条件 
2-8°C

Merck 
13,1020

应用领域

用途一
制取倍氯米松二丙酸酯。

安全数据

WGK Germany 
3

海关编码
29372900

制备方法

方法一
由地塞米松制得。

上下游产品信息

上游原料
地塞米松

常见问题列表

适应症
用于治疗湿疹、过敏性皮炎、神经性皮炎、扁平苔藓、盘状红斑狼疮、掌跖脓疱病、接触性皮炎、局限性银屑病、皮肤瘙痒症等。丙酸倍氯米松气雾剂用于慢性或过敏性哮喘及过敏性鼻炎等。
生物活性
Beclometasone (Beclomethasone) 是一种糖皮质激素受体 (glucocorticoid receptor) 激动剂。
靶点

Glucocorticoid Receptor


体外研究

An inhibition of the normal physiological neutrophil migration and of neutrophil chemotaxis directed by wounding-induced inflammation is detected at 4 h after administration of 25 μM Beclomethasone. Tumour cell invasion and micrometastasis is also reduced in embryos incubated in 25 μM Beclomethasone 4 h before implantation. In addition, the lysyl oxidase inhibitor β-aminoproprionitrile (βAPN) largely reduces fibrillar collagen and enhances the CHT-TF transmigration of neutrophils, leading to a significant increase of tumour cell invasion and subsequent formation of micrometastases. Notably, βAPN inhibits neutrophil chemotaxis induced by inflammation, indicating that the increase of tumour cell invasion in βAPN-treated embryos is correlated with enhanced non-pathological neutrophil migration, but not with inflammation.


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